Increased arterial stiffness in HIV-infected children: risk factors and antiretroviral therapy
Increased arterial stiffness in HIV-infected children: risk factors and antiretroviral therapy
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DOI：
10.3851/imp1437
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发表时间：
2009-01-01
影响因子：
1.2
通讯作者：
Klein, Nigel J.
中科院分区：
文献类型：
--
作者：
Charakida, Marietta;Loukogeorgakis, Stavros P.;Klein, Nigel J.
Background: Recent evidence suggests that both the HIV virus and antiretroviral therapy (ART) are associated with premature atherosclerosis in adults. Increased arterial stiffness as assessed by pulse wave velocity (PWV) has been associated with adverse cardiovascular outcome in adults. The relationship between HIV infection and treatment and arterial stiffness has not been evaluated in children.Methods: We studied 83 HIV-infected children with a mean +/- SD age of 11.0 +/- 3.1 years and 59 controls aged 12.2 +/- 2.8 years. Among the HIV-infected children, 48 were receiving ART (23 including a protease inhibitor). Arterial stiffness was assessed non-invasively by carotid-radial PWV. Disease severity was defined according to the CDC classification.Results: PWV was significantly increased in HIV-infected children compared with controls (P
