Measurement, correlation and thermodynamics of solubility of metronidazole in 2-(2-ethoxyethoxy)ethanol + water cosolvent mixtures at (298.15 to 333.15) K
Measurement, correlation and thermodynamics of solubility of metronidazole in 2-(2-ethoxyethoxy)ethanol + water cosolvent mixtures at (298.15 to 333.15) K
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DOI：
10.1016/j.molliq.2014.11.008
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发表时间：
2014-12
影响因子：
6
通讯作者：
F. Shakeel;N. Haq;F. Alanazi;I. Alsarra
中科院分区：
文献类型：
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作者：
F. Shakeel;N. Haq;F. Alanazi;I. Alsarra
本研究的目的是用摇瓶法测定甲硝唑（MTZ）在（2981.5 ~ 333.15）K范围内的2-（2-乙氧基乙氧基）乙醇+水混合物中的溶解度。MTZ的实验溶解度与Apelblat方程和Yalkowsky模型相关。Apelblat方程的均方根偏差百分比（% RMSD）为（0.80 ~ 4.51）%，Yalkowsky模型的均方根偏差百分比为（1.42 ~ 11.57）%。MTZ在纯2-（2-乙氧基乙氧基）乙醇中的溶解度最高（2.07 × 10−2,298.15 K）。在所有共溶剂混合物中，MTZ的溶解都是吸热自发的。根据目前的溶解性数据，MTZ被认为在纯水中微溶，在纯2-（2-乙氧基乙氧基）乙醇中可溶。
The aim of present study was to measure and correlate the solubility of metronidazole (MTZ) in various 2-(2-ethoxyethoxy)ethanol + water mixtures from (2981.5 to 333.15) K using the shake flask method. The experimental solubilities of MTZ were correlated with Apelblat equation and Yalkowsky model. The percent of root mean square deviations (% RMSD) was obtained as (0.80 to 4.51)% for Apelblat equation and (1.42 to 11.57)% for Yalkowsky model. The mole fraction solubility of MTZ was observed to be the highest in pure 2-(2-ethoxyethoxy)ethanol (2.07 × 10− 2at 298.15 K). The MTZ dissolution was observed as endothermic andspontaneousin all cosolvent mixtures. Based on current solubility data, MTZ has been considered as slightly soluble in pure water and soluble in pure 2-(2-ethoxyethoxy)ethanol.