Dynamic role of adult-born dentate granule cells in memory processing.
Dynamic role of adult-born dentate granule cells in memory processing.
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DOI：
10.1016/j.conb.2015.06.002
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发表时间：
2015-12
影响因子：
5.7
通讯作者：
Schinder AF
中科院分区：
文献类型：
--
作者：
Kropff E;Yang SM;Schinder AF
在包括人类在内的所有哺乳动物的整个成年生活中，新的神经元被并入海马的齿状回。在一个持续约两周的关键窗口期间，成年出生的未成熟神经元比成熟神经元更容易兴奋和可塑，并且它们对更广泛的输入做出反应。显然矛盾的是，新的神经元已经被证明是至关重要的，以解决行为任务，涉及非常相似的情况下，这将需要高输入特异性的歧视。我们认为，未成熟的神经元最初是非特异性的，因为它们的任务是识别高维输入空间内的新元素。随着成熟，它们将专门代表这些新输入的细节，有利于区分。
Throughout the adult life of all mammals including humans, new neurons are incorporated to the dentate gyrus of the hippocampus. During a critical window that lasts about two weeks, adult-born immature neurons are more excitable and plastic than mature ones, and they respond to a wider range of inputs. In apparent contradiction, new neurons have been shown to be crucial to solve behavioral tasks that involve the discrimination of very similar situations, which would instead require high input specificity. We propose that immature neurons are initially unspecific because their task is to identify novel elements inside a high dimensional input space. With maturation, they would specialize to represent details of these novel inputs, favoring discrimination.