Inflammasome-mediated cell death in response to bacterial pathogens that access the host cell cytosol: lessons from legionella pneumophila.
Inflammasome-mediated cell death in response to bacterial pathogens that access the host cell cytosol: lessons from legionella pneumophila.
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DOI：
10.3389/fcimb.2013.00111
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发表时间：
2013-12-27
影响因子：
5.7
通讯作者：
Shin S
中科院分区：
文献类型：
--
作者：
Casson CN;Shin S
Cell death can be critical for host defense against intracellular pathogens because it eliminates a crucial replicative niche, and pro-inflammatory cell death can alert neighboring cells to the presence of pathogenic organisms and enhance downstream immune responses. Pyroptosis is a pro-inflammatory form of cell death triggered by the inflammasome, a multi-protein complex that assembles in the cytosol to activate caspase-1. Inflammasome activation by pathogens hinges upon violation of the host cell cytosol by activities such as the use of pore-forming toxins, the use of specialized secretion systems, or the cytosolic presence of the pathogen itself. Recently, a non-canonical inflammasome has been described that activates caspase-11 and also leads to pro-inflammatory cell death. Caspase-11 is activated rapidly and robustly in response to violation of the cytosol by bacterial pathogens as well. In this mini-review, we describe the canonical and non-canonical inflammasome pathways that are critical for host defense against a model intracellular bacterial pathogen that accesses the host cytosol—Legionella pneumophila.
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影响因子：
29.7
作者：
Davis BK;Wen H;Ting JP
通讯作者：
Ting JP
DOI：
10.1074/jbc.m110.197681
发表时间：
2011-02-04
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Abdelaziz DH;Gavrilin MA;Akhter A;Caution K;Kotrange S;Khweek AA;Abdulrahman BA;Grandhi J;Hassan ZA;Marsh C;Wewers MD;Amer AO
通讯作者：
Amer AO
影响因子：
3.4
作者：
Amer, AO;Swanson, MS
通讯作者：
Swanson, MS
影响因子：
2.7
作者：
Boniotto, Michele;Tailleux, Ludovic;Quintana-Murci, Lluis
通讯作者：
Quintana-Murci, Lluis
影响因子：
3.4
作者：
Archer KA;Alexopoulou L;Flavell RA;Roy CR
通讯作者：
Roy CR