Brain infarction following 5-fluorouracil and cisplatin therapy
Brain infarction following 5-fluorouracil and cisplatin therapy
复制标题
5-氟尿嘧啶和顺铂治疗后脑梗塞
作者：
M. E. Amrani;O. Heinzlef;T. Debrouker;Etienne Roullet;Marchie‐Germaine Bousser;P. Amarenco
5例口咽癌患者输注5-氟尿嘧啶和顺铂后2~5天内发生缺血性卒中。这发生在三名患者的第二疗程化疗期间，以及两名患者的第三疗程期间。治疗与脑梗塞之间可能有联系，因为1)尽管进行了广泛的测试，包括一名患者的尸检，但没有发现其他原因；2)注射治疗与中风之间存在短暂的延迟；3)在第二或第三个疗程的化疗后，出现了类似的缺血性中风模式。
Five patients with oropharyngeal cancer treated with 5-fluorouracil and cisplatin had ischemic stroke within 2 to 5 days after the drug infusion. This occurred during the second course of chemotherapy in three patients, and during the third course in two patients. There may be a relation between treatment and brain infarction because 1) there was no other cause identified despite extensive tests, including postmortem examination in one patients; 2) there was a short delay between treatment infusion and stroke; and 3) there was a similar pattern of ischemic stroke after the second or third course of chemotherapy.