Fibroblast Senescence in Idiopathic Pulmonary Fibrosis.
Fibroblast Senescence in Idiopathic Pulmonary Fibrosis.
复制标题
特发性肺纤维化中的成纤维细胞衰老 。
DOI：
10.3389/fcell.2020.593283
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发表时间：
2020
影响因子：
5.5
通讯作者：
Xu Z
中科院分区：
文献类型：
--
作者：
Lin Y;Xu Z
随着年龄的增长，老龄化是一个不可避免的复杂的自然现象。细胞衰老是指一种非增殖性但仍有活力的细胞生理状态。它是衰老的基础，它存在于身体的任何时间点。特发性肺纤维化(IPF)是一种病因不明的间质性纤维性肺疾病，以肺结构和功能的不可逆性破坏为特征。衰老是IPF最重要的危险因素之一，广泛的流行病学数据证实IPF是一种与衰老相关的疾病。IPF中的衰老成纤维细胞表现为异常激活、端粒缩短、代谢重编程、线粒体功能障碍、凋亡抵抗、自噬缺陷和衰老相关分泌表型(SASP)。衰老成纤维细胞的这些特性建立了细胞衰老与IPF之间的密切联系。衰老相关分子和途径的治疗不断涌现，利用增龄剂消除衰老的成纤维细胞也被积极尝试作为治疗IPF的新方法。在这篇综述中，我们讨论了衰老和细胞衰老在IPF中的作用。特别是，我们总结了衰老的成纤维细胞影响IPF发生和发展的信号通路。在此基础上，进一步探讨了目前的治疗思路，希望本文能为今后的研究提供有益的参考。
Aging is an inevitable and complex natural phenomenon due to the increase in age. Cellular senescence means a non-proliferative but viable cellular physiological state. It is the basis of aging, and it exists in the body at any time point. Idiopathic pulmonary fibrosis (IPF) is an interstitial fibrous lung disease with unknown etiology, characterized by irreversible destruction of lung structure and function. Aging is one of the most critical risk factors for IPF, and extensive epidemiological data confirms IPF as an aging-related disease. Senescent fibroblasts in IPF show abnormal activation, telomere shortening, metabolic reprogramming, mitochondrial dysfunction, apoptosis resistance, autophagy deficiency, and senescence-associated secretory phenotypes (SASP). These characteristics of senescent fibroblasts establish a close link between cellular senescence and IPF. The treatment of senescence-related molecules and pathways is continually emerging, and using senolytics eliminating senescent fibroblasts is also actively tried as a new therapy for IPF. In this review, we discuss the roles of aging and cellular senescence in IPF. In particular, we summarize the signaling pathways through which senescent fibroblasts influence the occurrence and development of IPF. On this basis, we further talk about the current treatment ideas, hoping this paper can be used as a helpful reference for future researches.