Partition of calibrated tris-acryl gelatin microspheres in the arterial vasculature of embolized nasopharyngeal angiofibromas and paragangliomas
Partition of calibrated tris-acryl gelatin microspheres in the arterial vasculature of embolized nasopharyngeal angiofibromas and paragangliomas
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DOI：
10.1097/01.rvi.0000150038.99488.01
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发表时间：
2005-04-01
影响因子：
2.9
通讯作者：
Merland, JJ
中科院分区：
文献类型：
--
作者：
Laurent, A;Wassef, M;Merland, JJ
目的：确定经校准的三丙烯明胶微球（TGMs）在鼻咽血管纤维瘤（NAFs）和副神经节瘤（pg）动脉血管中的位置。材料和方法：用不同大小（100-300 μ m至900-1200 μ m）的tgm栓塞后手术处理的49例标本（25例pg和24例NAFs），用苏木精和伊红藏红花染色，用显微镜（放大倍数，X12.5）在物镜放大10或20倍的情况下进行分析。测定闭塞血管的直径、它们的定位（瘤内或瘤外）以及它们所含的tgm的数量和直径。结果：检测到栓塞血管（N = 1125）： pg组440条，NAFs组685条。89%的血管位于瘤内，11%位于瘤外。栓塞血管的直径随着TGMs的大小范围的增加而显著增加（P < 0.0001）。瘤内闭塞血管明显小于瘤外血管（P < 0.0001）。在NAFs和pg中，TGMs在血管网络内（肿瘤内或肿瘤外）的分布相似。当比较100-300亩的tgm与500-700亩的tgm （P = 0.0006）以及300-500亩的tgm与500-700亩的tgm时，tgm在瘤内和瘤外的传播不同（P = 0.0001）。结论：TGMs闭塞血管的大小及其在瘤内或瘤外的位置直接取决于注射TGMs的大小。位于肿瘤内部的血管比位于肿瘤外部的血管小。从这些数据可以提出TGMs在肿瘤内渗透血管的阈值。没有证据表明TGMs在NAFs和pg中有不同的行为。
PURPOSE: To determine the location of calibrated tris-acryl gelatin microspheres (TGMs) in the arterial vasculature of nasopharyngeal angiofibromas (NAFs) and paragangliomas (PGs).MATERIALS AND METHODS: Forty-nine specimens (25 PGs and 24 NAFs) treated operatively after embolization with TGMs of various sizes (100-300 mu m to 900-1200 mu m) were stained with hematoxylin and eosin saffron and analyzed at an objective magnification of 10 or 20 with a micrometric eyepiece (magnification, X12.5). The diameter of occluded vessels, their localization (intra- or extratumoral), and the number and diameter of TGMs they contained were determined.RESULTS: Embolized vessels (N = 1125) were measured: 440 in PGs and 685 in NAFs. Vessels were 89% intratumoral and 11% extratumoral. The diameter of the occluded vessels increased significantly with the size range of TGMs used for embolization for each tumor type (P < .0001). Intratumoral occluded vessels were significantly smaller than extratumoral vessels (P < .0001). Distribution of TGMs within the vascular network (intratumoral or extratumoral location) were similar for NAFs and PGs. The intratumoral and extratumoral dissemination of TGMs was different when comparing 100-300-mu m TGMs versus 500-700-mu m TGMs (P = .0006) as well as 300-500-mu m TGMs versus 500-700-mu m TGMs (P = .0001).CONCLUSIONS: The size of the vessels occluded by TGMs and their intra- or extratumoral location directly depend on the size of the injected TGMs. The vessels located inside the tumors were smaller than those located outside the tumors. A threshold for the intratumoral penetration of TGMs in the vasculature can be proposed from these data. There was no evidence of different behavior of TGMs in NAFs versus PGs.