Lingering prenatal effects of the 1918 influenza pandemic on cardiovascular disease.
Lingering prenatal effects of the 1918 influenza pandemic on cardiovascular disease.
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DOI：
10.1017/s2040174409990031
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发表时间：
2010-02
影响因子：
1.7
通讯作者：
Finch, C. E.
中科院分区：
文献类型：
--
作者：
Mazumder, B.;Almond, D.;Park, K.;Crimmins, E. M.;Finch, C. E.
在1982-1996年美国国家健康访谈调查中，出生前暴露于1918年流感大流行(甲型流感，H1N1亚型)与60至82岁时心血管疾病增加20%有关，相对于出生时未接触流感大流行的同龄人，产前或出生后(定义为出生后季度)≥。男性比女性表现出更强的流感对晚期缺血性心脏病增加的影响。1919年出生的人在第二次世界大战入伍时的成年身高低于在相邻年份出生的人，这表明发育迟缓。对产妇感染流行率的计算表明，产前接触即使不复杂的产妇流感也可能在以后的生活中产生持久的后果。这些发现表明，母体感染在胎儿心血管危险因素的规划中扮演了新的角色，这些因素与母亲营养不良无关。
Prenatal exposure to the 1918 influenza pandemic (Influenza A, H1N1 subtype) is associated with ≥20% excess cardiovascular disease at 60 to 82 years of age, relative to cohorts born without exposure to the influenza epidemic, either prenatally or postnatally (defined by the quarter of birth), in the 1982–1996 National Health Interview Surveys of the USA. Males showed stronger effects of influenza on increased later ischemic heart disease than females. Adult height at World War II enlistment was lower for the 1919 birth cohort than for those born in adjacent years, suggesting growth retardation. Calculations on the prevalence of maternal infections indicate that prenatal exposure to even uncomplicated maternal influenza may have lasting consequences later in life. These findings suggest novel roles for maternal infections in the fetal programming of cardiovascular risk factors that are independent of maternal malnutrition.