Nutrition and subsequent hip fracture risk among a national cohort of white women
Nutrition and subsequent hip fracture risk among a national cohort of white women
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DOI：
10.1093/oxfordjournals.aje.a008899
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发表时间：
1996-07-15
影响因子：
5
通讯作者：
McGovern, PG
中科院分区：
文献类型：
--
作者：
Huang, ZP;Himes, JH;McGovern, PG
本研究采用第一次全国健康与营养调查（NHANES I）流行病学随访研究的前瞻性数据，调查了一般营养状况（饮食摄入量、生化标志物和人体测量）与随后发生髋部骨折风险的三个方面。在1971-1975年参加NHANES I调查的2,513名45岁及以上的白色女性队列随后分别在1982-1984年、1986年和1987年进行了三次随访研究。在基线时测量多个营养变量，并在随访期间通过医院记录或死亡证明确定了130例髋关节骨折事件。考克斯回归分析显示，基线膳食能量摄入、血清白蛋白、体重、体重指数、皮褶厚度和手臂肌肉面积与随后的髋部骨折风险呈显著负相关（这些变量增加1个标准差的相对风险范围为0.68至0.83）。作者认为，营养状况差，明显表现为饮食摄入不足、血清白蛋白降低、体重和软组织减少，会增加随后发生髋部骨折的风险。该研究还表明，年龄和既往骨折史是重要的风险因素;然而，自我报告的体力活动，产次和饮酒与随后的髋部骨折无关。
This study investigated three aspects of general nutritional status (dietary intake, biochemical markers, and anthropometric measurements) in relation to subsequent hip fracture risk by using prospective data from the First National Health and Nutrition Examination Survey (NHANES I) epidemiologic follow-up studies. A cohort of 2,513 white women 45 years and over who participated in the NHANES I survey in 1971-1975 were subsequently followed in the three follow-up studies in 1982-1984, 1986, and 1987, respectively. Multiple nutritional variables were measured at baseline, and 130 incident hip fractures were identified by hospital records or by death certificates during the follow-up period. Cox regression analyses showed that baseline dietary energy intake; serum albumin; and weight, body mass index, skinfold, and arm muscle area were significantly acid inversely related to subsequent hip fracture risk (relative risks for a 1-standard deviation increment in these variables ranged from 0.68 to 0.83). The authors suggest that poor nutritional status, evident in inadequate dietary intake, reduced serum albumin, and decreased body mass and soft tissues, increases the risk for subsequent hip fracture. The study also showed that age and previous fracture history were significant risk factors; however, self-reported physical activity, parity, and alcohol use were not significantly related to subsequent hip fracture.