From the Infectious Diseases Society of America. Guidelines for the use of antimicrobial agents in neutropenic patients with unexplained fever.
From the Infectious Diseases Society of America. Guidelines for the use of antimicrobial agents in neutropenic patients with unexplained fever.
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来自美国传染病学会。
DOI：
--
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发表时间：
1990
影响因子：
6.4
通讯作者：
M. Yow
中科院分区：
文献类型：
--
作者：
W. Hughes;D. Armstrong;GeraldP. Bodey;R. Feld;G. Mandell;J. Meyers;P. Pizzo;S. Schimpff;J. Shenep;James C. Wade;L. Young;M. Yow
这是美国传染病学会针对抗菌治疗问题的一系列报告之一。发热的贫血病人被感染的可能性大于60%.如果中性粒细胞计数<100个细胞/1 L，20%或更多的发热事件将伴有菌血症[1，2]。主要由需氧革兰氏阴性杆菌（尤其是大肠杆菌、肺炎克雷伯氏菌和铜绿假单胞菌）和革兰氏阳性球菌（尤其是凝固酶阴性葡萄球菌、α-溶血性链球菌和金黄色葡萄球菌）引起[3]（表1）。真菌是接受广谱抗生素治疗的贫血患者继发感染的常见原因。这类患者特别难以评估，因为使其粒细胞减少的因素导致炎症反应受损。因此，炎症的迹象是无声的，需要在病史和体格检查时特别考虑。值得注意的是，受影响的地点相对较少，这些感染的原因有限
This is one in a series of reports by the Infectious Diseases Society of America to address issues in antimicrobial therapy. The neutropenic patient who becomes febrile has a >60 % likelihood of being infected. If the neutrophil count is <100 cells/1l, ,v20% or more of febrile episodes will have an associated bacteremia [1, 2]. These are caused principally by aerobic gram-negative bacilli (especially Escherichia coli, Kiebsiella pneumoniae, and Pseudomonas aeruginosa) and gram-positive cocci (in particular, coagulase-negative staphytococci, a-hemolytic streptococci, and Staphylococcus aureus) [3] (table 1). Fungi are common causes of secondary infections among neutropenic patients who have received courses of broad-spectrum antibiotics. Such patients are particularly difficult to evaluate because the factors that have rendered them granulocytopenic have resulted in an impaired inflammatory response. Therefore, the signs of inflammation are muted, requiring special consideration during historytaking and physical examination. It is notable that relatively few sites are affected and the cause of these infections is limited
头孢哌酮加哌拉西林双 β-内酰胺治疗发热性粒细胞减少症患者的对照试验。
DOI：
10.1016/0002-9343(88)90171-4
发表时间：
1988
期刊：
The American journal of medicine
影响因子：
--
作者：
Winston,DJ;Ho,WG;Bruckner,DA;Gale,RP;Champlin,RE
通讯作者：
Champlin,RE
莫沙内酰胺加哌拉西林与莫沙内酰胺加阿米卡星治疗发热性粒细胞减少症患者的比较。
DOI：
10.1016/0002-9343(84)90100-1
发表时间：
1984
期刊：
The American journal of medicine
影响因子：
--
作者：
Winston,DJ;Barnes,RC;Ho,WG;Young,LS;Champlin,RE;Gale,RP
通讯作者：
Gale,RP
氧氟沙星与万古霉素/多粘菌素用于预防粒细胞减少症患者的感染。
DOI：
10.1016/0002-9343(90)90125-w
发表时间：
1990
期刊：
The American journal of medicine
影响因子：
--
作者：
Winston,DJ;Ho,WG;Bruckner,DA;Gale,RP;Champlin,RE
通讯作者：
Champlin,RE