Continuation therapy with lithium and amitriptyline in unipolar depressive illness: a randomized, double-blind, controlled trial
Continuation therapy with lithium and amitriptyline in unipolar depressive illness: a randomized, double-blind, controlled trial
复制标题
锂和阿米替林继续治疗单相抑郁症：一项随机、双盲、对照试验
作者：
A. Glen;A. Johnson;M. Shepherd
一项多中心临床试验结果的详细分析表明，虽然手术定义的抑郁症患者在接受阿米替林或锂治疗后恢复的复发率低于安慰剂，但两种抗抑郁药物的预防效果在临床上没有显著差异。叙述了治疗的相对不利影响，并讨论了研究结果的含义。
Synopsis A detailed analysis of the results of a multi-centre clinical trial shows that, while the relapse rate following recovery from an operationally defined depressive illness was smaller among patients subsequently treated with either amitryptiline or lithium than with a placebo, there was no clinically significant difference between the prophylactic efficacy of the 2 antidepressants. An account is given of the relative adverse effects of the treatments, and the implications of the findings are discussed.