LONG-TERM SURVIVAL AFTER EDMONSTON-ZAGREB MEASLES VACCINATION IN GUINEA-BISSAU - INCREASED FEMALE MORTALITY-RATE
LONG-TERM SURVIVAL AFTER EDMONSTON-ZAGREB MEASLES VACCINATION IN GUINEA-BISSAU - INCREASED FEMALE MORTALITY-RATE
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DOI：
10.1016/s0022-3476(09)90015-4
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发表时间：
1993-06-01
影响因子：
5.1
通讯作者：
DASILVA, MC
中科院分区：
文献类型：
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作者：
AABY, P;KNUDSEN, K;DASILVA, MC
在几内亚比绍的一个城市地区，384名儿童参加了一项随机试验，比较了从4个月大开始接种高滴度埃德蒙顿-萨格勒布（EZ）麻疹疫苗后的发病率和死亡率，对照组在4个月大时接种灭活脊髓灰质炎疫苗，9个月大时接种标准施瓦茨疫苗。儿童被跟踪到至少3岁。如果在迁移时排除儿童，EZ疫苗接种者与对照受试者相比的死亡率为1.79（范围，1.06至3.02; p = 0.027）;如果包括迁移后的死亡，死亡率为1.53（范围，0.94至2.49; p = 0.087）。EZ组女孩的死亡率显著高于对照组女孩（死亡率= 1.95;范围：1.07 - 3.56; p = 0.027）;男孩之间没有差异（死亡率= 0.98;范围：0.41 - 2.30）。在考克斯回归模型中对背景因素进行调整并没有改变这些估计值。此外，EZ疫苗的女性接种者有更多的腹泻天数（相对危险度= 1.35;范围：1.17 - 1.56; p = 0.00003），并且在接种疫苗后一个月内，（相对危险度= 1.86;范围：1.05 - 3.31; p = 0.027）;咨询者随后死亡的可能性更大（死亡率比= 2.31;范围：0.99 - 5.41; p = 0.054）。这些观察结果是计划外的，需要在更大规模的研究中确认。
In an urban area of Guinea-Bissau, 384 children were enrolled in a randomized trial comparing morbidity and mortality rates after receiving high-titer Edmonston-Zagreb (EZ) measles vaccine administered from 4 months of age, with a control group receiving inactivated poliomyelitis vaccine at 4 months of age and the standard Schwarz vaccine from 9 months of age. Children were followed to the age of at least 3 years. The mortality ratio of the EZ vaccinees compared with control subjects was 1.79 (range, 1.06 to 3.02; p = 0.027) if children were excluded at the time of migration; if deaths after migration were included, the mortality ratio was 1.53 (range, 0.94 to 2.49; p = 0.087). Girls in the EZ group had significantly higher mortality rates than girls in the control group (mortality ratio = 1.95; range, 1.07 to 3.56; p = 0.027); there was no difference for the boys (mortality ratio = 0.98; range, 0.41 to 2.30). Adjustment for background factors in a Cox regression model did not modify these estimates. Furthermore, female recipients of EZ vaccine had more days with diarrhea (relative risk = 1.35; range, 1.17 to 1.56; p = 0.00003) and were more likely than control subjects to visit a health center in the month after vaccination (relative risk = 1.86; range, 1.05 to 3.31; p = 0.027); those who consulted were more likely to die subsequently (mortality ratio = 2.31; range, 0.99 to 5.41; p = 0.054). These observations were unplanned and require confirmation in larger studies.