Fhit down-regulation is an early event in pancreatic carcinogenesis.
Fhit down-regulation is an early event in pancreatic carcinogenesis.
复制标题
下调是胰腺癌发生的早期事件。
DOI：
10.1007/s00428-017-2105-3
复制
发表时间：
2017-06
期刊：
影响因子：
--
通讯作者：
Huebner K
中科院分区：
文献类型：
--
作者：
Fassan M;Rusev B;Corbo V;Gasparini P;Luchini C;Vicentini C;Mafficini A;Paiella S;Salvia R;Cataldo I;Scarpa A;Huebner K
FHIT的异常表达是很大一部分胰腺导管腺癌(PDAC)的特征，但FHIT在胰腺导管上皮多步转化过程中的表型变化过程中的表达尚不完全清楚。我们用免疫组织化学方法检测了FHIT在胰腺上皮内瘤变(Panin)和导管内乳头状粘液瘤(IPMN)两种不同的多步胰腺癌过程中的表达。我们考虑了105个手术治疗的PDAC/IPMN，选择了30例非肿瘤性胰腺实质、50例PAIN病变、30例IPMN、15例伴发浸润性癌的IPMN和60例腺癌。正常胰管及其周围的腺泡细胞始终呈中到强的FHIT免疫反应。在这两种致癌过程中，随着发育不良/肿瘤严重程度的增加，FHIT表达显著下调。通过研究从同一手术标本获得的多个病变，进一步证实了这一点。在60例PDAC中，仅14例FHIT表达与正常胰腺导管上皮相当，其余(77%)FHIT表达明显阴性或降低。这项研究表明，在导致PDAC的两个多步骤致癌过程中，FHIT下调是一个早期事件。
Aberrant Fhit expression characterizes a large proportion of primary pancreatic ductal adenocarcinomas (PDACs), but fragmentary information is available on Fhit expression during the phenotypic changes of pancreatic ductal epithelium during multistep transformation. We assessed Fhit expression by immunohistochemistry in two different multistep pancreatic carcinogenic processes: pancreatic intraepithelial neoplasia (PanIN) and intraductal papillary mucinous neoplasia (IPMN). We considered 105 surgically treated PDACs/IPMNs and selected: 30 samples of non-neoplastic pancreatic parenchyma, 50 PanIN lesions, 30 IPMNs, 15 IPMNs with associated invasive carcinoma and 60 adenocarcinomas. Normal pancreatic ducts and surrounding acinar cells consistently showed moderate to strong Fhit immunoreactivity. Significant down-regulation of Fhit expression was observed in association with increasing severity of dysplastia/neoplastia in both carcinogenic processes. This was further confirmed by studying multiple lesions obtained from the same surgical specimen. Of 60 PDACs, only 14 showed Fhit expression comparable to normal pancreatic ductal epithelium, while the remainder (77%) showed clearly negative or reduced Fhit expression. This study demonstrates that Fhit down-regulation is an early event in both multistep carcinogenic processes leading to PDAC.
登录
查看更多内容
影响因子：
64.8
作者：
Bartkova, J;Horejsi, Z;Bartek, J
通讯作者：
Bartek, J
影响因子：
7.3
作者：
Amato, Eliana;dal Molin, Marco;Mafficini, Andrea;Yu, Jun;Malleo, Giuseppe;Rusev, Borislav;Fassan, Matteo;Antonello, Davide;Sadakari, Yoshihiko;Castelli, Paola;Zamboni, Giuseppe;Maitra, Anirban;Salvia, Roberto;Hruban, Ralph H.;Bassi, Claudio;Capelli, Paola;Lawlor, Rita T.;Goggins, Michael;Scarpa, Aldo
通讯作者：
Scarpa, Aldo
影响因子：
5.7
作者：
Karras JR;Schrock MS;Batar B;Zhang J;La Perle K;Druck T;Huebner K
通讯作者：
Huebner K
影响因子：
2.9
作者：
Baumgart, Mario;Werther, Meike;Heinmoeller, Ernst
通讯作者：
Heinmoeller, Ernst
DOI：
10.1097/pas.0000000000000533
发表时间：
2015-12
期刊：
The American journal of surgical pathology
影响因子：
--
作者：
Basturk O;Hong SM;Wood LD;Adsay NV;Albores-Saavedra J;Biankin AV;Brosens LA;Fukushima N;Goggins M;Hruban RH;Kato Y;Klimstra DS;Klöppel G;Krasinskas A;Longnecker DS;Matthaei H;Offerhaus GJ;Shimizu M;Takaori K;Terris B;Yachida S;Esposito I;Furukawa T;Baltimore Consensus Meeting
通讯作者：
Baltimore Consensus Meeting