Acid-promoted cascade cyclization to produce fused-polycyclic indole derivatives.
Acid-promoted cascade cyclization to produce fused-polycyclic indole derivatives.
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DOI：
10.1021/ol401128h
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发表时间：
2013-06
期刊：
影响因子：
5.2
通讯作者：
Takuya Yokosaka;Hiroki Nakayama;T. Nemoto;Y. Hamada
中科院分区：
文献类型：
--
作者：
Takuya Yokosaka;Hiroki Nakayama;T. Nemoto;Y. Hamada
描述了一种酸促进的新型级联环化反应。使用8当量的三氟乙酸或催化量的刘易斯酸作为促进剂，以中等至优异的产率获得结构多样的多环戊二烯并[B]吲哚。该级联过程对于合成八元环稠环并环戊二烯并[B]吲哚衍生物是非常有效的。
An acid-promoted novel cascade cyclization is described. Using 8 equiv of trifluoroacetic acid or a catalytic amount of Lewis acid as the promoter, structurally diverse polycyclic cyclopenta[b]indoles were obtained in moderate to excellent yield. This cascade process was extremely effective for the synthesis of 8-membered ring-fused cyclopenta[b]indole derivatives.