The Effect of a Ceramide-Containing Product on Stratum Corneum Lipid Levels in Dry Legs
The Effect of a Ceramide-Containing Product on Stratum Corneum Lipid Levels in Dry Legs
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DOI：
10.36849/jdd.2020.4796
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发表时间：
2020-04-01
影响因子：
1.5
通讯作者：
Colon, Gene
中科院分区：
文献类型：
--
作者：
Draelos, Zoe D.;Baalbaki, Nada H.;Colon, Gene
大致等摩尔浓度的神经酰胺、胆固醇和游离脂肪酸排列成片状，形成角质层（SC）中的细胞间脂质屏障。细胞间脂质缺乏（特别是神经酰胺）和屏障破坏与许多皮肤病（包括皮肤干燥）有关。本研究通过将临床观察与生化分析相结合以定量SC细胞间脂质水平，探讨了皮肤干燥体征改善与SC中神经酰胺含量之间的关系。在一项对皮肤干燥、瘙痒的女性受试者进行的随机、双盲、分腿研究中，评价了一种多层囊泡乳剂（MVE）、含神经酰胺的保湿霜的疗效，该霜增加了皮肤水合作用，并表现出立即和持续减少皮肤干燥的可见体征和受试者感知的感觉不适。此外，在保湿剂应用4周后，SC中的神经酰胺、胆固醇和游离脂肪酸水平显著增加。因此，含神经酰胺的保湿霜对干燥、瘙痒皮肤的临床效果伴随着SC细胞间脂质水平的增加。
Roughly equimolar concentrations of ceramides, cholesterol, and free fatty acids arranged in lamellar sheets form the intercellular lipid barrier in the stratum corneum (SC). Intercellular lipid deficiencies, specifically ceramides, and barrier disruption are associated with many dermatologic conditions, including dry skin. This study explored the relationship between the improvement in the signs of dry skin and the amounts of ceramides in the SC by combining clinical observations with a biochemical analysis to quantify the level of SC intercellular lipids. The efficacy of a multilamellar vesicular emulsion (MVE), ceramide-containing moisturizing cream was evaluated in a randomized, investigator-blinded, split-leg study on female subjects with dry, itchy skin.The cream increased skin hydration and demonstrated an immediate and sustained reduction in the visible signs of dry skin and subject perceived sensory discomfort. Additionally, ceramide, cholesterol and free fatty acid levels in the SC significantly increased after 4 weeks of moisturizer application. Thus, the clinical effect of the ceramide-containing moisturizing cream on dry, itchy skin was accompanied by an increase in SC intercellular lipid levels.