Combined local treatment and chemotherapy in the management of bilateral retinoblastomas in Hungary
Combined local treatment and chemotherapy in the management of bilateral retinoblastomas in Hungary
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DOI：
10.1097/00043426-200606000-00016
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发表时间：
2006-06-01
影响因子：
1.2
通讯作者：
Kiss, C
中科院分区：
文献类型：
--
作者：
Sohajda, Z;Damjanovich, J;Kiss, C
这项回顾性研究支持近距离放射治疗结合细胞生长抑制治疗可能有效地有助于肿瘤控制。对13例双侧视网膜母细胞瘤患者的第一只眼眼球摘除后，对第二只眼进行了斑块近距离放射治疗。11例患者接受了全身细胞抑制治疗。平均随访时间为60（+/- 42 SD）个月。12名患者存活且无肿瘤，其中8名视力可接受。细胞抑制治疗后，2例患者出现晚期肾病。总之，近距离放射治疗结合细胞抑制治疗将是一种选择，在双侧视网膜母细胞瘤的管理后，眼球摘除的第一只眼睛。
This retrospective study supports that brachytherapy combined with cytostatic therapy may effectively contribute to tumor control. The second eye of 13 patients with bilateral retinoblastoma was treated with plaque brachytherapy after the enucleation of the first eye. Eleven patients received systemic cytostatic therapy. The mean follow up was 60 (+/- 42 SD) months. Twelve patients are alive and free of tumor, 8 of them with acceptable visual acuity. After cytostatic therapy, late nephropathy was observed in 2 patients. In conclusion, brachytherapy combined with cytostatic therapy will be an option in the management of bilateral retinoblastoma after the enucleation of the first eye.