Protection against human immunodeficiency virus type 1 infection in persons with repeated exposure: Evidence for T cell immunity in the absence of inherited CCR5 coreceptor defects
Protection against human immunodeficiency virus type 1 infection in persons with repeated exposure: Evidence for T cell immunity in the absence of inherited CCR5 coreceptor defects
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DOI：
10.1086/314632
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发表时间：
1999-03-01
影响因子：
6.4
通讯作者：
McElrath, MJ
中科院分区：
文献类型：
--
作者：
Goh, WC;Markee, J;McElrath, MJ
据推测，对人类免疫缺陷病毒（HIV）-1感染的保护可能来自获得性宿主免疫、功能失调的CCR 5 HIV-1辅助受体的遗传，或低或减毒的病毒接种物，37名未感染艾滋病毒1的人与艾滋病毒1感染者反复进行高风险性活动，感染的伴侣进行了前瞻性研究，以确定这些因素在预防HIV-1传播中的作用。超过三分之一（13/36）的受试者表现出HIV-1特异性细胞毒性，并且这种活性与野生型CCR 5基因型显著相关（P = 0.03），只有1例受试者（3%）表现出纯合CCR 5 32-bp缺失（Delta 32/Delta 32）。中位血浆HIV-1 RNA水平从18个HIV-1感染的性伴侣没有统计学差异，从匹配的感染对照患者。这些结果表明，Delta 32 CCR 5突变的遗传并不能解释大多数持续性HIV-1耐药病例，这些人中细胞免疫的存在表明未被发现的感染或保护性免疫。
It has been hypothesized that protection against human immunodeficiency virus (HIV)-1 infection may result from either acquired host immunity, inheritance of a dysfunctional CCR5 HIV-1 coreceptor, or a low or attenuated virus inoculum, Thirty-seven HIV-1-uninfected persons engaging in repeated high-risk sexual activity with an HIV-1-infected partner were prospectively studied to determine the contribution of these factors in protecting against HIV-1 transmission. More than one-third (13/36) demonstrated HIV-1-specific cytotoxicity, and this activity significantly correlated with the wild type CCR5 genotype (P = .03), Only 1 subject (3%) demonstrated the homozygous CCR5 32-bp deletion (Delta 32/Delta 32). Median plasma HIV-1 RNA levels from 18 HIV-1-infected sex partners were not statistically different from those of matched infected control patients. These results indicate that inheritance of the Delta 32 CCR5 mutation does not account for the majority of persistently HIV-1-resistant cases, and the presence of cellular immunity in these persons suggests either undetected infection or protective immunity.