Block Telomer-Carrying Amphiphiles Prepared with a Phospholipid Iniferter†
Block Telomer-Carrying Amphiphiles Prepared with a Phospholipid Iniferter†
复制标题
用磷脂引发转移剂制备嵌段端粒携带两亲物†
作者：
H. Kitano;Minae Chibashi;and Shizue Nakamata;M. Ide
以4-（N，N-二乙基二硫代氨甲酰甲基）苯甲酸琥珀酰亚胺酯（BDC-OSu）为原料，分别与硬脂胺（SA）和1-α-二棕榈酰磷脂酰乙醇胺（DPPE）偶联，合成了两种亲脂性化合物SA-BDC和DPPE-BDC。在SA-BDC和N，N，N '，N'-四乙基秋兰姆二硫化物（TD）存在下，通过光照射甲基丙烯酸甲酯（MMA），得到了以MMA调聚物为头基的新型脂质（SA-PMMA）。SA-PMMA的数均分子量（Mn）随着辐照时间的增加而增加，而分散性指数（Mw/Mn）约为1.2，这表明SA-BDC作为引发剂，追求所谓的活性自由基聚合。同样地，在DPPE-BDC和TD存在下，通过光照射甲基丙烯酸（MA），获得了携带MA调聚物的新型磷脂（DPPE-PMA）。脂质的Mw/Mn值为1.12 2小时后开始的光照射，这表明DPPE-BDC作为iniferter，太。两亲性DPPE-...
Novel lipophilic compounds, SA-BDC and DPPE-BDC, were prepared by the coupling of 4-(N,N-diethyldithiocarbamylmethyl)benzoic acid succinimidyl ester (BDC-OSu) with stearylamine (SA) and l-α-dipalmitoyl phosphatidylethanolamine (DPPE), respectively. By the photoirradiation of methyl methacrylate (MMA) in the presence of SA-BDC and N,N,N‘,N‘-tetraethylthiuram disulfide (TD), a novel lipid with a MMA telomer as the head group was obtained (SA-PMMA). The number average molecular weight (Mn) of SA-PMMA increased with the irradiation time while the dispersivity index (Mw/Mn) was around 1.2, which showed that SA-BDC worked as an iniferter which pursues a so-called living radical polymerization. Similarly, by the photoirradiation of methacrylic acid (MA) in the presence of DPPE-BDC and TD, a MA telomer-carrying novel phospholipid was obtained (DPPE-PMA). The Mw/Mn value of the lipid was 1.12 2 h after the onset of the photoirradiation, which showed that DPPE-BDC worked as the iniferter, too. The amphiphilic DPPE-...