Spatially localized 31P NMR measurements of longitudinal relaxation rates in the canine myocardium.
Spatially localized 31P NMR measurements of longitudinal relaxation rates in the canine myocardium.
复制标题
犬心肌纵向弛豫率的空间局部 31P NMR 测量。
DOI：
10.1002/mrm.1910290616
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发表时间：
1993
影响因子：
3.3
通讯作者：
Robitaille,PM
中科院分区：
文献类型：
--
作者：
Rath,DP;Abduljalil,AM;Robitaille,PM
FLAX-ISIS空间定位与反转恢复相结合，以测量空间定位的T1值。这种方法被应用于跨壁测定磷酸肌酸在犬心肌的纵向弛豫时间。通过检查跨越左心肌壁的5个体素，我们观察到，在4.7特斯拉下，磷酸肌酸的透壁T1值范围为3.61 = 0.20（内膜）至4.00 ± 0.20（心外膜）。因此，犬心肌磷酸肌酸的T1值无跨壁变化。这种简单的方法可以扩展到体内测量跨壁酶速率。
FLAX‐ISIS spatial localization was combined with inversion recovery to enable the measurement of spatially localizedT1values. This approach was applied to the transmural determination of creatine phosphate longitudinal relaxation times in the canine myocardium. By examining five voxels spanning the left myocardial wall, we observed that transmuralT1values for creatine phosphate ranged from 3.61 = 0.20 in the endocardium to 4.00 ± 0.20 in the epicardium at 4.7 Tesla. As such, the canine myocardium exhibits no transmural variation in theT1values of creatine phosphate. This simple approach can be extended to enable thein vivomeasurement of transmural enzymatic rates.