Evidence for deficit in tasks of ventral, but not dorsal, prefrontal executive function as an endophenotypic marker for bipolar disorder
Evidence for deficit in tasks of ventral, but not dorsal, prefrontal executive function as an endophenotypic marker for bipolar disorder
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DOI：
10.1016/j.biopsych.2005.05.020
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发表时间：
2005-11-15
影响因子：
10.6
通讯作者：
Kumari, V
中科院分区：
文献类型：
--
作者：
Frangou, S;Haldane, M;Kumari, V
背景：BD患者的特质功能异常仅在腹侧前额叶皮质（VPFC）中有报道。我们研究是否赤字VPFC相关的抑制过程，但不背前额叶（DPFC）为基础的执行功能，双相情感障碍I（BDI）的一个内表型标记。方法：我们使用的威斯康星州卡片分类测试（WCST），通常与DPFC功能，和海林句子完成任务（HSCT）从事的VPFC。43名健康受试者的这些测试的性能进行了比较，10个缓解的BDI患者和15个未受影响的后代。结果：与健康受试者相比，患者和他们的后代在HSCT中犯了更多的错误，但后代在WCST中实现了更多的类别和更少的持续性错误。受损的反应抑制，主要是VPFC相关的功能，可能反映家族易感性BDI，而赤字的规则实现，DPFC为基础的功能，可能只与临床表型。
Background: Trait functional abnormalities in BD patients have only been reported in the ventral prefrontal cortex (VPFC). We examined whether deficits in VPFC-related inhibitory processes, but not dorsal prefrontal (DPFC) based executive functions, represent an endophenotypic marker for bipolar disorder I (BDI).Methods: We used the Wisconsin Card Sorting Test (WCST), commonly associated with DPFC function, and the Hayling Sentence Completion Task (HSCT) which engaged the VPFC. Performance on these tests of 43 healthy participants was compared to that of 10 remitted BDI patients and 15 of their unaffected offspring.Results: Compared to healthy participants, patients and their offspring made more errors in the HSCT but offspring achieved more categories and made fewer perserverative errors in the WCST.Conclusions: Impaired response inbhition, predominantly a VPFC related function, may reflect familial predisposition to BDI while deficits in rule attainment, a DPFC based function, may be associated only with the clinical phenotype.