Comparison of the efficacy of electroacupuncture Baihui (GV 20) and Yintang (EX-HN 3) and western medicine in treating depression post-schizophrenia
Comparison of the efficacy of electroacupuncture Baihui (GV 20) and Yintang (EX-HN 3) and western medicine in treating depression post-schizophrenia
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DOI：
10.1016/j.wjam.2018.03.016
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发表时间：
2018-03-01
影响因子：
0.7
通讯作者：
Cao, Minyou
中科院分区：
文献类型：
--
作者：
Lu, Huipeng;Ma, Peizhen;Cao, Minyou
目的：观察电针百会印堂（EX-HN 3）与口服盐酸舍曲林治疗精神分裂症后抑郁症的临床疗效差异。方法：将60例精神分裂症后抑郁症患者按1：1的比例随机分为电针组和西药组，每组30例。两组患者均给予抗精神病药物作为基础治疗。电针组加用GV 20、EX-HN 3电针，每次30 min，隔日1次。每周治疗3次，持续6周。西药组在此基础上口服盐酸舍曲林，每日1次，连续6周。采用总体评估量表（GAS）评估两组患者治疗前后的综合状况。采用汉密尔顿抑郁量表-17（HAMD-17）评估两组患者治疗前、治疗后1周、2周、4周、治疗后及随访时的抑郁程度。结果：两组患者治疗后GAS评分均高于治疗前（均P＜0.05），但两组患者治疗后GAS评分差异无统计学意义。 HAMD-17：电针组患者治疗前、治疗1周、2周、4周、治疗后及随访期间6个时间点HAMD-17评分逐渐降低，且相邻2个时间点评分差异均有统计学意义（均P < 0.05）。西药组患者HAMD-17评分在6个时间点逐渐降低，治疗2周、4周、治疗后相邻两个时间点评分差异均有统计学意义（均P < 0.05）。电针组患者治疗1周、2周、4周后HAMD-17评分均低于西药组，差异均有统计学意义（均P < 0.05）。结论：电针GV 20、EX-HN 3与口服盐酸舍曲林治疗精神分裂症后抑郁症临床疗效比较，整体病情得到改善有效且差异无统计学意义。电针治疗抑郁症起效较快，作用持续时间较长。 (C) 2018 年由 Elsevier B.V. 代表世界针灸杂志社出版。
Objective: To observe the clinical efficacy difference between electroacupuncture at Baihui (GV 20) and Yintang (EX-HN 3) and oral administration of sertraline hydrochloride for treatment of post-schizophrenic depression.Methods: Sixty patients with post-schizophrenic depression were randomly divided into electroacupuncture group and western medicine group in the proportion of 1:1, with 30 patients in each group. The patients in the two groups were all given antipsychotics as the basic treatment. Electroacupuncture at GV 20 and EX-HN 3 was performed additionally in electroacupuncture group with 30 min/time and once every other day. The treatment was given for 3 times a week, lasting for 6 weeks. Oral administration of sertraline hydrochloride was given in western medicine group additionally for once a day, lasting for 6 weeks. The comprehensive conditions of patients in the two groups were evaluated before and after treatment by adopting Global Assessment Scale (GAS). The degree of depression of patients in the two groups was assessed before treatment, after treatment for 1 week, 2 weeks and 4 weeks, after treatment as well as during follow-up visit by adopting Hamilton Depression Scale-17 (HAMD-17).Results: GAS: GAS scores of the patients in the two groups after treatment were higher than those before treatment (both P < 0.05), but the difference of GAS scores of the patients in the two groups after treatment was not statistically significant. HAMD-17: The HAMD-17 scores of patients in electroacupuncture group reduced gradually in the six time points of before treatment, after treatment for 1 week, 2 weeks and 4 weeks, after treatment as well as during follow-up visit, and the differences of scores between the two adjacent time points were statistically significant (all P < 0.05). The HAMD-17 scores of patients in western medicine group reduced gradually in the 6 time points, and the differences of scores between the two adjacent time points among after treatment for 2 weeks and 4 weeks, and after treatment were statistically significant (all P < 0.05). The HAMD-17 scores of patients in electroacupuncture group were lower than that in western medicine group after treatment for 1 week, 2 weeks and 4 weeks, and the differences were statistically significant (all P < 0.05).Conclusion: According to the comparison of the clinical efficacies of electroacupuncture at GV 20 and EX-HN 3 and oral administration of sertraline hydrochloride for treatment of post-schizophrenic depression, the overall conditions were improved effectively and the difference was not statistically significant. Electroacupuncture takes effect more rapidly in treatment of depression, and its effect can last for a longer time. (C) 2018 Published by Elsevier B.V. on behalf of World Journal of Acupuncture Moxibustion House.