Polymorphisms in the CISH gene are associated with susceptibility to tuberculosis in the Chinese Han population
Polymorphisms in the CISH gene are associated with susceptibility to tuberculosis in the Chinese Han population
复制标题
CISH基因多态性与中国汉族人群结核病易感性相关。
DOI：
10.1016/j.meegid.2014.10.006
复制
发表时间：
2014-12-01
影响因子：
3.2
通讯作者：
Xu, Jin
中科院分区：
文献类型：
--
作者：
Ji, Lin-dan;Xu, Wei-nan;Xu, Jin
最近的一项多中心病例对照研究确定了在非洲和亚洲人群中与结核病（TB）易感性相关的尼古丁诱导SRC同源2结构域（CISH）基因内的几个单核苷酸多态性（SNP）。为了获得这些SNPs对结核病易感性的假定影响的更可靠和更有效的估计，我们在中国汉族人群中进行了一项设计良好的病例对照研究。我们对600例肺结核患者和618例健康对照者的CISH中3个先前确定的SNP进行了基因分型，并计算了在中国人群中进行的几项研究的合并P值和OR。病例对照研究结果显示，rs2239751的C等位基因和rs414171的T等位基因与结核病易感性相关，并且这种关联仅存在于女性和年轻人中。汇总分析表明，这两个SNP与全球人群和中国人群中的结核病显著相关。目前的研究证实，CISH的变体与结核病的易感性有关，这表明细胞因子信号传导的负调节因子可能在抗结核感染的免疫中起作用。我们假设CISH和雌激素可能在免疫系统的细胞因子依赖性调节中相互作用。(C)2014爱思唯尔有限公司版权所有。
A recent multi-center case-control study identified several single nucleotide polymorphisms (SNPs) within the cytokine-inducible SRC homology 2 domain (CISH) gene that are associated with susceptibility to tuberculosis (TB) in both African and Asian populations. To acquire a more robust and well-powered estimate of the putative influence of these SNPs on TB susceptibility, we conducted a well-designed case-control study in the Chinese Han population. We genotyped 3 previously identified SNPs within CISH in 600 patients with pulmonary TB and 618 healthy controls, and we calculated the pooled P-values and ORs of several studies that have also been conducted in the Chinese populations. The results of the case-control study showed that the C allele of rs2239751 and the T allele of rs414171 are associated with TB susceptibility, and this association exists only in women and young adults. The pooled analysis indicated that both SNPs are significantly associated with TB in the global populations and Chinese populations. The current study confirms that variants of CISH are associated with susceptibility to TB, suggesting that negative regulators of cytokine signaling may have a role in immunity against TB infection. We hypothesize that CISH and estrogen may interact in the cytokine-dependent regulation of the immune system. (C) 2014 Elsevier B.V. All rights reserved.