Intratumoral Heterogeneity of the Epigenome.
Intratumoral Heterogeneity of the Epigenome.
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DOI：
10.1016/j.ccell.2016.03.009
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发表时间：
2016-04-11
期刊：
影响因子：
50.3
通讯作者：
Costello JF
中科院分区：
文献类型：
--
作者：
Mazor T;Pankov A;Song JS;Costello JF
对表观基因组瘤内异质性（ITH）的研究正处于形成阶段。从表观遗传 ITH 和遗传 ITH 推断出的肿瘤进化模式非常相似，表明这些不同机制之间存在广泛的相互依赖性。表观遗传 ITH 的生物学和临床相关性正变得越来越明显。具有独特且可逆表观遗传状态的罕见肿瘤细胞可能会导致耐药性，而诊断时的表观遗传 ITH 程度可以预测患者的预后。这一视角介绍了表观遗传 ITH 的当前概念和临床意义，以及 ITH 探索前沿的实验和计算技术。
Investigation into intratumoral heterogeneity (ITH) of the epigenome is in a formative stage. The patterns of tumor evolution inferred from epigenetic ITH and genetic ITH are remarkably similar, suggesting widespread co-dependency of these disparate mechanisms. The biological and clinical relevance of epigenetic ITH are becoming more apparent. Rare tumor cells with unique and reversible epigenetic states may drive drug resistance, and the degree of epigenetic ITH at diagnosis may predict patient outcome. This perspective presents these current concepts and clinical implications of epigenetic ITH, and the experimental and computational techniques at the forefront of ITH exploration.