Changes in airway function and bronchial responsiveness after acute occupational exposure to chlorine leading to treatment in a first aid unit
Changes in airway function and bronchial responsiveness after acute occupational exposure to chlorine leading to treatment in a first aid unit
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DOI：
10.1136/oem.55.5.356
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发表时间：
1998-05-01
影响因子：
4.9
通讯作者：
Gautrin, D
中科院分区：
文献类型：
--
作者：
Leroyer, C;Malo, JL;Gautrin, D
Objectives-To描述基线特征和时间进程或工人意外吸入高浓度的氯在前瞻性study.Methods-Baseline肺功能的变化进行了肺功能测定和乙酰甲胆碱激发试验在一个队列的278名工人意外吸入氯的风险。意外吸入导致在急救单位的干预工人进行重新评估5至25天后，事故和串行此后当有显着的changes.Results-During一个为期四年的随访期间，13名工人被认为是在急救单位后，有症状的意外吸入。其中3人经历了显著的功能变化：一名工人经历了一秒钟用力呼气量（FEV 1）下降10%，另外两名工人的乙酰甲胆碱浓度显著下降，导致FEV 1（PC 20）下降20%。两名工人是吸烟者，一名有过敏症的个人病史。这三名工人的基线评估在正常范围内。恢复是完整的三个月后，意外inhalation. Conclusion，短暂的，但显着的气道功能下降或支气管反应性的增加，可能会发生意外吸入高浓度的氯在工人的风险。
Objectives-To describe the baseline characteristics ana the time course or changes in lung function in workers accidentally inhaling high concentrations of chlorine in a prospective study.Methods-Baseline spirometry and methacholine challenge test were performed in a cohort of 278 workers at risk of accidental inhalation of chlorine. Workers in whom accidental inhalation led to intervention in a first aid unit were reassessed five to 25 days after the accident and serially thereafter when there where notable changes.Results-During a four year follow up period, 13 workers were seen at the first aid unit after a symptomatic accidental inhalation. Three of them experienced notable functional changes: one worker experienced a 10% fall in forced expiratory volume in one second (FEV1), and the other two had a notable fall in the concentration of methacholine that caused a 20% fall in FEV1 (PC20). Two workers were smokers and one had a personal history of atopy. Baseline assessment was within the normal range in these three workers. Recovery was complete three months after the accidental inhalation.Conclusion-Transient but notable decreases in airway function or increases in bronchial responsiveness can occur after an accidental inhalation of high concentrations of chlorine in workers at risk.