Chiral tetraaminophosphonium carboxylate-catalyzed direct Mannich-type reaction.
Chiral tetraaminophosphonium carboxylate-catalyzed direct Mannich-type reaction.
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DOI：
10.1021/ja806311e
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发表时间：
2008-10
影响因子：
15
通讯作者：
D. Uraguchi;Y. Ueki;T. Ooi
中科院分区：
文献类型：
--
作者：
D. Uraguchi;Y. Ueki;T. Ooi
手性羧酸四氨基磷（P，S）-1的协同不对称催化。OCOR已经建立，并成功应用于氮唑内酯与n -磺酰基亚胺的高对映选择性直接mannich型反应。本研究通过对有机阴离子进行结构修饰，激发了手性季铵盐催化潜力的培养。
The cooperative asymmetric catalysis of chiral tetraaminophosphonium carboxylate (P,S)-1.OCOR has been established, and its synthetic utility has been successfully demonstrated by application to the highly enantioselective direct Mannich-type reaction of azlactones with N-sulfonyl imines. The present study stimulates the cultivation of the potential of the chiral quaternary onium salt catalysis by the structural modification of organic anion.