dishevelled is required during wingless signaling to establish both cell polarity and cell identity.
dishevelled is required during wingless signaling to establish both cell polarity and cell identity.
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发表时间：
1994-02
期刊：
影响因子：
4.6
通讯作者：
Heidi Theisen;Judith M. Purcell;M. Bennett;Dipul Kansagara;A. Syed;J. Marsh
中科院分区：
文献类型：
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作者：
Heidi Theisen;Judith M. Purcell;M. Bennett;Dipul Kansagara;A. Syed;J. Marsh
果蝇的凌乱基因是建立极化细胞的连贯阵列所必需的，也是在胚胎中建立片段所必需的。在这里，我们表明，在克隆中，在双杂合子与无翼突变体和苍蝇携带一个弱的凌乱的转基因导致模式化缺陷，单独在无翼突变体中观察到的表型缺陷凌乱的功能损失。此外，极化细胞在所有的身体节需要凌乱的功能，以建立平面细胞极性，和一些无翅等位基因和凌乱的;无翅双杂合子表现出刚毛极性缺陷中看到的那些单独凌乱。在细胞自主性中建立极性的要求。该基因编码一种新的细胞内蛋白，该蛋白与其他几种与细胞连接相关的蛋白共享一个氨基酸基序。在腿盘凌乱的克隆分析提供了一个独特的机会来检验的假设，即无翼凌乱的相互作用物种的极坐标模型预测的圆周位置值中的至少一个。我们建议，蓬乱编码细胞内蛋白质需要响应无翼信号，这种相互作用是必不可少的，建立细胞极性和细胞身份。
The dishevelled gene of Drosophila is required to establish coherent arrays of polarized cells and is also required to establish segments in the embryo. Here, we show that loss of dishevelled function in clones, in double heterozygotes with wingless mutants and in flies bearing a weak dishevelled transgene leads to patterning defects which phenocopy defects observed in wingless mutants alone. Further, polarized cells in all body segments require dishevelled function to establish planar cell polarity, and some wingless alleles and dishevelled; wingless double heterozygotes exhibit bristle polarity defects identical to those seen in dishevelled alone. The requirement for dishevelled in establishing polarity in cell autonomous. The dishevelled gene encodes a novel intracellular protein that shares an amino acid motif with several other proteins that are found associated with cell junctions. Clonal analysis of dishevelled in leg discs provides a unique opportunity to test the hypothesis that the wingless dishevelled interaction species at least one of the circumferential positional values predicted by the polar coordinate model. We propose that dishevelled encodes an intracellular protein required to respond to a wingless signal and that this interaction is essential for establishing both cell polarity and cell identity.