Practical production of 61Cu using natural Co target and its simple purification with a chelating resin for 61Cu-ATSM
Practical production of 61Cu using natural Co target and its simple purification with a chelating resin for 61Cu-ATSM
复制标题
DOI：
10.1524/ract.92.4.209.35593
复制
发表时间：
2004-01-01
影响因子：
1.8
通讯作者：
Suzuki, K
中科院分区：
文献类型：
--
作者：
Fukumura, T;Okada, K;Suzuki, K
用两种方法从辐照靶中分离出Co-59（α，2n）Cu-61核反应生成的Cu-61（T-1/2 = 3.41 h），并用于制备缺氧组织显像剂（Cu-61-ATSM）（Cu-61-diacetyl-bis（N-4-methylthiosemicarbazone））。用40 MeV（靶上37.9 MeV）α粒子照射市售钴盘（厚度：125 μ m），然后用浓HNO 3处理，并通过两种不同的方法分离Cu-61，即使用阳离子和阴离子交换柱的双柱法;和使用填充有螯合树脂Chelex 100的柱的单柱法。这两种分离方法都得到了满意的结果，尽管后一种方法由于设备简单、分离步骤和处理时间稍短而优越于前一种方法，但仍有上级优点。在10 I-LA条件下，Co靶辐照1h，61 Cu（2+）的产率（衰变校正）>95%，放射性核素纯度>98%（EOS），得到约1.1GBq的61 Cu（2+）。在EOS时，分离的Cu-61（2+）溶液中唯一的放射性核素杂质被鉴定为Cu-60，但50小时后没有观察到放射性核素杂质。Cu-61-ATSM的溶液以>85%的放射化学产率和>95%的放射化学纯度制备。
Copper-61 (T-1/2 = 3.41 h) produced via the Co-59(alpha, 2n)Cu-61 nuclear reaction using natural Co target was isolated from the irradiated target by two methods developed here and applied for preparation of (Cu-61-ATSM) (Cu-61-diacetyl-bis(N-4-methylthiosemicarbazone)), known as an imaging agent of hypoxic tissue. A commercially available cobalt disk (thickness: 125 mum) was irradiated with 40 MeV (37.9 MeV on target) a particles, then treated with conc. HNO3, and the Cu-61 was separated by two different methods, i.e. a two column method using a cation and an anion exchange column; and a one Column method using a column packed with chelating resin, Chelex 100. Both separation methods gave satisfactory results, though the latter method was superior because of the simplicity of the apparatus, the separation procedure and somewhat shorter processing time. Around 1.1 GBq of 61Cu(2+) were obtained with >95% yield (decay corrected) from Co target at 10 I-LA for 1 h irradiation, and with the radionuclidic purity of >98% (EOS). The only radionuclidic impurity in the isolated Cu-61(2+) solution was identified to be Cu-60 at EOS but no radionuclidic impurity was observed after 50 hours. The solution of Cu-61-ATSM was prepared in >85% radiochemical yield with >95% radiochemical purity.