Negative life events and quality of life in adults with asthma
Negative life events and quality of life in adults with asthma
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DOI：
10.1136/thx.2006.065730
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发表时间：
2007-02-01
期刊：
影响因子：
10
通讯作者：
Blanc, P. D.
中科院分区：
文献类型：
--
作者：
Archea, C.;Yen, I. H.;Blanc, P. D.
背景：成人哮喘患者的压力与生活质量之间的关系尚未得到很好的研究。由负性生活事件量化的压力可能通过多种途径与哮喘患者的生活质量联系在一起，包括疾病严重程度的增加和对社会经济地位(SES)的不良影响。方法：分析189名来自特征良好的队列的成人哮喘患者对过去12个月负性生活事件(NLE)的自我填写问卷的反应。使用Marks工具测量报告的NLEs数量与哮喘特有的生活质量(AQOL)之间的关系。结果：家庭年收入80%的人预测NLEs、SES和疾病严重度之间的联合效应。NLES的出现频率与较差(数值得分较高)的生活质量相关(p=0.002)。在同一模型中共同研究时，收入水平、哮喘严重程度(哮喘严重程度评分；p<；0.001)和NLE数量(P=0.03)的组合都与AQOL显著相关。结论：NLE与成人哮喘患者的生活质量有关，特别是在SES较低的患者中。临床医生应该意识到这种关系，特别是在脆弱的患者亚群中。
Background: The relationship between stress and quality of life in adults with asthma has not been well studied. Stress, quantified by negative life events, may be linked to quality of life in asthma through multiple pathways, including increase in disease severity and adverse effects on socioeconomic status ( SES).Methods: The responses to a self- completed questionnaire assessing negative life events (NLEs) in the previous 12 months ( from a 24- item checklist) among 189 adults with asthma from a well- characterised cohort were analysed. The relationship between the number of NLEs reported and asthma- specific quality of life ( AQOL) was measured with the Marks instrument. General linear modelling was used to test the conjoint effects of NLEs, SES and disease severity based on the Severity of Asthma Score, a validated acute and chronic disease measure.Results: Those with annual family incomes 80% predicted, nor among those with lower compared with higher Severity of Asthma Score. The frequency of NLEs was associated with poorer ( higher numerical score) AQOL ( p = 0.002). When studied together in the same model, combinations of income level and asthma severity ( greater or lesser Severity of Asthma Score; p < 0.001) and number of NLEs ( p = 0.03) were both significantly associated with AQOL.Conclusion: NLEs are associated with quality of life among adults with asthma, especially among those of lower SES. Clinicians should be aware of this relationship, especially in vulnerable patient subsets.