LIGHT-INDUCED SUPPRESSION OF ENDOGENOUS CIRCADIAN AMPLITUDE IN HUMANS
LIGHT-INDUCED SUPPRESSION OF ENDOGENOUS CIRCADIAN AMPLITUDE IN HUMANS
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DOI：
10.1038/350059a0
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发表时间：
1991-03-07
期刊：
影响因子：
64.8
通讯作者：
CZEISLER, CA
中科院分区：
文献类型：
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作者：
JEWETT, ME;KRONAUER, RE;CZEISLER, CA
WINFREE 于 20 年前报道了一项有趣的发现，即在关键昼夜节律阶段施加临界强度的光刺激，可以通过将昼夜节律振荡器重置到接近其奇点（昼夜节律振荡幅度为零的无相位置），从本质上停止果蝇中的昼夜节律时钟。从那时起，对响应关键刺激的昼夜节律幅度衰减的类似观察仅限于单细胞、昆虫和植物2-7。 我们最近证明，可以使用非常规的三周期刺激 8,9 来反转人类昼夜节律起搏器的相位，这使我们研究了在严格定时暴露于更温和的刺激下是否可以将振荡器推向奇点。 在这里，我们报告说，人类暴露在较少周期的强光下，以人类昼夜节律起搏器对光引起的相移最敏感的时间为中心，可以显着减弱内源性昼夜节律振幅。 在某些情况下，这会导致节律性明显丧失，正如预期发生在奇点区域的那样。
WINFREE reported 20 years ago the intriguing finding that a light stimulus of a critical strength applied at a critical circadian phase could essentially stop the circadian clock in Drosophila pseudo-obscura by resetting the circadian oscillator close to its singularity (a phaseless position at which the amplitude of circadian oscillation is zero) 1. Since then, similar observations of attenuated circadian amplitude in response to critical stimuli have been limited to unicells, insects and plants 2-7. Our recent demonstration that the phase of the human circadian pacemaker could be inverted using an unconventional three-cycle stimulus 8,9 led us to investigate whether critically timed exposure to a more moderate stimulus could drive that oscillator towards its singularity. Here we report that exposure of humans to fewer cycles of bright light, centred around the time at which the human circadian pacemaker is most sensitive to light-induced phase shifts, can markedly attenuate endogenous circadian amplitude. In some cases this results in an apparent loss of rhythmicity, as expected to occur in the region of singularity.