Exercise as a Countermeasure to Declining Central Nervous System Function in Multiple Sclerosis
Exercise as a Countermeasure to Declining Central Nervous System Function in Multiple Sclerosis
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DOI：
10.1016/j.clinthera.2017.12.001
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发表时间：
2018-01-01
影响因子：
3.2
通讯作者：
Sandroff, Brian M.
中科院分区：
文献类型：
--
作者：
Mot, Robert W.;Sandroff, Brian M.
目的：中枢神经系统（CNS）功能下降是多发性硬化症（MS）的标志特征，可表现为认知障碍。我们认为，运动代表了一种潜在的行为方法，可以抵消多发性硬化症患者中枢神经系统结构和相关功能的下降（即，运动作为中枢神经系统下降的对策）。这一理论很重要，因为疾病修饰药物代表了修饰免疫系统及其对中枢神经系统影响的一线方法，但这些药物通常没有显示出对认知表现的强有力改善。方法：据我们所知，本文提出了第一个将运动定位为多发性硬化症中枢神经系统衰退对策的论点。发现：所回顾的研究表明，越来越多的证据表明，身体健康、体育活动和运动对多发性硬化症患者的认知表现和神经影像学结果（即中枢神经系统功能）有影响，并且这一人群的认知表现和神经影像学结果之间存在一致和强烈的关联。(C) 2018 Elsevier HS Journals, Inc.；版权所有。
Purpose: The decline of central nervous system (CNS) function is a hallmark characteristic of multiple sclerosis (MS) that can manifest as cognitive impairment. We believe that exercise represents a potential behavioral approach for counteracting the declines in CNS structure and associated function among persons with MS (ie, exercise as a countermeasure of CNS decline). This theory is important because disease modifying drugs represent a first-line approach for modifying the immune system and its effects on the CNS, but these drugs do not generally demonstrate robust improvements in cognitive performance.Methods: To the best of our knowledge, this article presents the first argument positioning exercise as a countermeasure for CNS decline in MS.Finding: The reviewed research indicates a proliferating body of evidence describing physical fitness, physical activity, and exercise effects on cognitive performance and neuroimaging outcomes (ie, CNS functioning) in MS, with the consistent and strong association between cognitive performance and neuroimaging outcomes in this population as a backdrop. (C) 2018 Elsevier HS Journals, Inc. All rights reserved.