Neuroendocrine differentiation: The mysterious fellow of colorectal cancer
Neuroendocrine differentiation: The mysterious fellow of colorectal cancer
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DOI：
10.3748/wjg.v21.i41.11740
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发表时间：
2015-11-07
影响因子：
4.3
通讯作者：
Poetsch, Micaela
中科院分区：
文献类型：
--
作者：
Kleist, Britta;Poetsch, Micaela
散发性结直肠癌的神经内分泌分化已经被认识了几十年，但其临床影响仍有争议。详细的参数分析提示，可能不是神经内分泌分化本身，而是其与肿瘤分化程度差、淋巴结转移、远处转移和其他不利特征的相关性导致了更差的临床结局。然而，其他研究否认神经内分泌分化与结直肠癌预后之间的关系。这篇综述阐明了，是否有新的见解在肠上皮细胞的神经内分泌分化的起源，其调节mTOR通路组件和其可能的链接到肠干细胞隔室可以确定神经内分泌细胞作为预后标志物和假定的治疗靶点在散发性结直肠癌的作用。
Neuroendocrine differentiation in sporadic colorectal cancer has been recognized since decades, but its clinical impact is still controversially discussed. Detailed parameter analyses hint at the possibility that probably not neuroendocrine differentiation itself, but its association with poor grade of tumor differentiation, lymph node metastases, distant metastases and other unfavorable features contribute to worse clinical outcome. However, other studies deny a relationship between neuroendocrine differentiation and prognosis of colorectal cancer. This review elucidates, whether new insights into the origin of neuroendocrine differentiation in the intestinal epithelium, its regulation by mTOR pathway components and its possible link to the intestinal stem cell compartment could determine a role of neuroendocrine cells as prognostic marker and putative therapeutic target in sporadic colorectal cancer.