Charge-conversion ternary polyplex with endosome disruption moiety: A technique for efficient and safe gene delivery
Charge-conversion ternary polyplex with endosome disruption moiety: A technique for efficient and safe gene delivery
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DOI：
10.1002/anie.200800963
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发表时间：
2008-01-01
影响因子：
16.6
通讯作者：
Kataoka, Kazunori
中科院分区：
文献类型：
--
作者：
Lee, Yan;Miyata, Kanjiro;Kataoka, Kazunori
（图中所示）包装用于特殊递送：具有基于电荷转换聚合物pAsp（DET-Aco）的内体破坏部分的三元复合物显示出血清稳定性和低细胞毒性的负电荷，但电荷变为正电荷，内体破坏部分暴露（见图）。用原代细胞观察到高转染效率和最小的细胞毒性。
(Figure Presented) Wrapped for special delivery: A ternary polyplex, with an endosomal disruption moiety based on the charge-conversion polymer pAsp (DET-Aco), showed negative charges for serum stability and low cytotoxicity, but the charges became positive and the endosome disruption moiety was exposed (see picture). High transfection efficiency and minimal cytotoxicity were observed with primary cells.