Discriminative Stimulus Properties of Benzodiazepines and Barbiturates
Discriminative Stimulus Properties of Benzodiazepines and Barbiturates
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苯二氮卓类药物和巴比妥类药物的辨别刺激特性
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发表时间：
1977
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通讯作者：
F. Colpaert
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作者：
F. Colpaert
在本章中，我们将介绍和讨论一些数据的歧视性刺激特性的苯二氮卓类药物和其他相关药物。第一组数据是指用苯二氮卓类、巴比妥类和神经安定类药物在训练区分5 mg/kg氯氮卓类和盐水的大鼠中进行的刺激泛化实验。在该研究中获得的结果（Colpaert等人，1976 b）讨论了与相同药物的许多其他药物相关的作用。第二组数据总结了大量的拮抗实验，其目的是更具体地确定苯二氮卓类线索所依据的药理作用。这里提出的结果和结论的一个主要限制是，它们来自单一类型的辨别训练（Colpaert等人，197 6a），在测试前30分钟仅口服一种药物（氯氮卓）的一次训练剂量（5 mg/kg）。
In the present chapter we will present and discuss some data on the discriminative stimulus properties of benzodiazepines and pharmacologically related drugs. The first set of data refers to stimulus generalization experiments with benzodiazepines, barbiturates and neuroleptics in rats trained to discriminate 5 rag/kg chlor-diazepoxide from saline. The results obtained in that study (Colpaert et al., 1976b) are discussed in relation to a number of other pharmacologically relevant actions of the same drugs. A second set of data summarizes a large number of antagonism experiments the purpose of which was to identify somewhat more specifically the pharmacological action upon which the benzodiazepine cue is based. A major limitation of the results and conclusions presented here is, that they are derived from a single type of discrimination training (Colpaert et al., 197 6a) with only one training dose (5 mg/kg) of one drug (chlordiazepoxide) administered orally 30 min before test.