Abnormal fixational eye movements in strabismus
Abnormal fixational eye movements in strabismus
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DOI：
10.1136/bjophthalmol-2017-310346
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发表时间：
2018-02-01
影响因子：
4.1
通讯作者：
Shaikh, Aasef G.
中科院分区：
文献类型：
--
作者：
Ghasia, Fatema F.;Otero-Millan, Jorge;Shaikh, Aasef G.
摘要注视性眼跳是一种微小的眼球运动，在试图注视的过程中不断地改变注视。视觉引导的扫视和注视性扫视代表了视觉连续体，并且由共同的神经机制产生。斜视患者有非共轭双眼水平扫视。我们研究的稳定性和变化性的眼睛位置在固定在斜视患者和相关的严重程度，固定不稳定性与斜视角和双眼vision.Methods眼动测量13例斜视和16个控制在固定和视觉引导下的单眼观看条件下扫视。固定扫视和眼间漂移进行了分析，在观看和非观看眼睛的斜视患者和controls.Results我们发现，斜视患者的固定不稳定性增加与对照组相比。我们还发现，与对照组相比，斜视患者的注视扫视和眼球内漂移的不共轭性增加。大角度斜视和立体视缺失患者的不共轭性更差。斜视患者在漂移过程中眼位变化增加。我们的研究结果表明，这两个固定扫视和扫视间漂移是异常的，可能有助于固定不稳定的斜视patients with strabism.Discussion可能是一个有用的工具，大规模筛查的儿童弱视和潜伏性眼球震颤的情况下，诊断斜视。斜视患者注视眼球运动和视觉引导扫视的不共轭性增加反映了这些患者负责实现双眼融合的运动和视觉系统的微调中断。
Introduction Fixational saccades are miniature eye movements that constantly change the gaze during attempted visual fixation. Visually guided saccades and fixational saccades represent an oculomotor continuum and are produced by common neural machinery. Patients with strabismus have disconjugate binocular horizontal saccades. We examined the stability and variability of eye position during fixation in patients with strabismus and correlated the severity of fixational instability with strabismus angle and binocular vision.Methods Eye movements were measured in 13 patients with strabismus and 16 controls during fixation and visually guided saccades under monocular viewing conditions. Fixational saccades and intersaccadic drifts were analysed in the viewing and non-viewing eye of patients with strabismus and controls.Results We found an increase in fixational instability in patients with strabismus compared with controls. We also found an increase in the disconjugacy of fixational saccades and intrasaccadic ocular drift in patients with strabismus compared with controls. The disconjugacy was worse in patients with large-angle strabismus and absent stereopsis. There was an increase in eye position variance during drifts in patients with strabismus. Our findings suggest that both fixational saccades and intersaccadic drifts are abnormal and likely contribute to the fixational instability in patients with strabismus.Discussion Fixational instability could be a useful tool for mass screenings of children to diagnose strabismus in the absence of amblyopia and latent nystagmus. The increased disconjugacy of fixational eye movements and visually guided saccades in patients with strabismus reflects the disruption of the fine-tuning of the motor and visual systems responsible for achieving binocular fusion in these patients.