Synchrotron Light Source Applied to Measuring the Vacuum Ultraviolet Circular Dichroism of Heparin
Synchrotron Light Source Applied to Measuring the Vacuum Ultraviolet Circular Dichroism of Heparin
复制标题
同步光源用于测定肝素真空紫外圆二色性
DOI：
10.1021/ja00296a030
复制
发表时间：
1985
影响因子：
15
通讯作者：
J. Sutherland
中科院分区：
文献类型：
--
作者：
E. S. Stevens;E. Morris;D. Rees;J. Sutherland
Heparin2 是一种糖胺聚糖，在治疗上广泛用作抗凝剂和抗血脂剂。它是己糖胺和糖醛酸的线性交替共聚物，其主要重复二糖单元（图1）为2-磺胺基-2-脱氧D-吡喃葡萄糖基-6-硫酸酯和-L-吡喃糖醛酸2-硫酸酯，两个键均为(1—*-4)。存在显着的微观异质性，其主要特征包括作为次要糖醛酸组分出现/JD-吡喃葡萄糖醛酸、作为次要己糖胺组分出现2-乙酰氨基-2-脱氧-α-D-吡喃葡萄糖、不完全硫酸化，每个二糖的硫酸基数范围为大约2.0至2.5，以及分子量多分散性，平均分子量在范围为 8000 至 15000。
Heparin2 is a glycosaminoglycan widely used therapeutically as an anticoagulant and antilipemic agent. It is a linear alternating copolymer of a hexosamine and uronic acid, with a predominant repeating disaccharide unit (Figure 1) of 2-sulfamino-2-deoxyaD-glucopyranosyl-6-sulfate and-L-idopyranosyluronic acid 2-sulfate with both linkages being (1—*-4). Substantial microheterogeneity exists, the major features of which includethe occurrence of/JD-glucopyranosyluronic acid as a minor uronic acid component, the occurrence of 2-acetamido-2-deoxy-aD-glucopyranose as a minor hexosamine component, incomplete sulfation, with the number of sulfate groups per disaccharide ranging from approximately 2.0 to 2.5, andmolecular weight polydispersity, with mean molecular weights in the range of 8000 to 15 000.