The Relationship Between Blood Lead Level and Preeclampsia.
The Relationship Between Blood Lead Level and Preeclampsia.
复制标题
血液铅水平和先兆子痫之间的关系。
DOI：
10.19082/3450
复制
发表时间：
2016-12
影响因子：
--
通讯作者：
Mellati A
中科院分区：
文献类型：
--
作者：
Bayat F;Akbari SA;Dabirioskoei A;Nasiri M;Mellati A
铅是一种重金属，人们经常接触。由这种有毒金属引起的组织损伤的可能机制之一是氧化应激，这反过来可能导致许多妊娠并发症，如先兆子痫。本研究旨在探讨孕妇血铅水平与子痫前期的关系。本病例对照研究对2015年8月至2016年3月在伊朗赞詹一家医院住院的158名孕妇进行。为了测量他们的BLL，从每个参与者抽取1.5 cc血液。患者的人口统计学和产科详细信息记录在表格中。采用电位滴定法对样品进行测试。所得资料以SPSS 22版进行统计分析，使用Mann-Whitney U检定、卡方检定、独立样本t检定、Pearson积差相关及简单线性回归分析。对照组BLL平均值为6.24±1.74 μg/dl，先兆子痫组为8.04±3.4 μg/dl。两组在母亲的年龄、教育程度和家庭收入方面相匹配。观察到BLL与先兆子痫之间存在显著相关性（p=0.028），因为BLL每增加1单位（1 μg/dl），收缩压增加0.014 mm Hg，舒张压增加0.013 mm Hg（p=0.004）。所获得的结果表明BLL和先兆子痫之间的关系。应采取全球卫生措施，消除铅接触，以减少孕妇对铅的吸收。
Lead is a heavy metal to which people are commonly exposed. One of the possible mechanisms of tissue damages caused by this toxic metal is oxidative stress, which in turn may cause numerous pregnancy complications such as preeclampsia. The present study was conducted to determine the relationship between maternal Blood Lead Level (BLL) and preeclampsia. The present case-control study was conducted on 158 pregnant women admitted to a hospital in Zanjan, Iran, from August 2015 to March 2016. To measure their BLL, 1.5 cc of blood was drawn from each participant. The demographic and obstetric details of the patients were recorded in a form. The potentiometric method was used to test the samples. The data obtained were analyzed by SPSS version 22, using Mann-Whitney U test, the Chi square, independent-samples t-test, Pearson product-moment correlation, and simple linear regression analysis. The mean BLL was 6.24±1.74 μg/dl in the control group and 8.04±3.4 μg/dl in the preeclampsia group. The two groups were matching in terms of the mother’s age and education and the household income. A significant relationship was observed between BLL and preeclampsia (p=0.028), as per every unit of increase (1 μg/dl) in BLL, systolic blood pressure increased by 0.014 mm Hg and diastolic blood pressure by 0.013 mm Hg (p=0.004). The results obtained suggest a relationship between BLL and preeclampsia. Global health measures should be taken to remove the exposure to lead so as to reduce its absorption by pregnant women.