Total body skeletal muscle and adipose tissue volumes: estimation from a single abdominal cross-sectional image
Total body skeletal muscle and adipose tissue volumes: estimation from a single abdominal cross-sectional image
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DOI：
10.1152/japplphysiol.00744.2004
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发表时间：
2004-12-01
影响因子：
3.3
通讯作者：
Heshka, S
中科院分区：
文献类型：
--
作者：
Shen, W;Punyanitya, M;Heshka, S
在检查脂肪组织 (AT) 分布的研究中，通常会获得单个腹部横截面计算机轴向断层扫描和磁共振图像。腹部图像还可以提供有关全身骨骼肌 (SM) 和 AT 体积的额外有用信息以及相关的生理见解。因此，我们通过大量不同的健康成人受试者样本中的单张图像和全身成分体积研究了腹部 SM 和 AT 区域之间的关系。全身 SM 和 AT 体积通过 123 名男性的全身多层磁共振成像得出 [年龄（平均 +/- SD）为 41.6 +/- 15.8 岁；体重指数为 25.9 +/- 3.4 kg/m(2)] 和 205 名女性（年龄为 47.8 +/- 18.7 岁；体重指数为 26.7 +/- 5.6 kg/m(2)）。单腹部 SM 和 AT 切片面积分别与全身 SM（r = 0.71 - 0.92；r = 0.90，L-4 - L-5 椎间隙）和 AT（r = 0.84 - 0.96；r = 0.94，L-4 - L-5 椎间隙）体积高度相关。当模型中包含受试者性别、年龄、种族、扫描位置、体重指数和腰围时，SM 的 R-2 仅增加 5.7 - 6.1%，AT 的 R-2 仅增加 2.7 - 4.4%。开发的 SM 和 AT 模型在另外 49 名受试者中得到了验证。为了达到与测量全身 SM 或 AT 体积的研究同等的功效，使用单个腹部图像的研究需要多 17 - 24% 的 SM 受试者和 6 - 12% 的 AT 受试者。因此，单个腹部图像的测量可以为健康成人的小组研究提供全身 SM 和 AT 的估计。
A single abdominal cross-sectional computerized axial tomography and magnetic resonance image is often obtained in studies examining adipose tissue (AT) distribution. An abdominal image might also provide additional useful information on total body skeletal muscle (SM) and AT volumes with related physiological insights. We therefore investigated the relationships between abdominal SM and AT areas from single images and total body component volumes in a large and diverse sample of healthy adult subjects. Total body SM and AT volumes were derived by whole body multislice magnetic resonance imaging in 123 men [ age ( mean +/- SD) of 41.6 +/- 15.8 yr; body mass index of 25.9 +/- 3.4 kg/m(2)] and 205 women ( age of 47.8 +/- 18.7 yr; body mass index of 26.7 +/- 5.6 kg/m(2)). Single abdominal SM and AT slice areas were highly correlated with total body SM ( r = 0.71 - 0.92; r = 0.90 at L-4 - L-5 intervertebral space) and AT ( r = 0.84 - 0.96; r = 0.94 at L-4 - L-5 intervertebral space) volumes, respectively. R-2 increased by only 5.7 - 6.1% for SM and 2.7 - 4.4% for AT with the inclusion of subject sex, age, ethnicity, scanning position, body mass index, and waist circumference in the model. The developed SM and AT models were validated in an additional 49 subjects. To achieve equivalent power to a study measuring total body SM or AT volumes, a study using a single abdominal image would require 17 - 24% more subjects for SM and 6 - 12% more subjects for AT. Measurement of a single abdominal image can thus provide estimates of total body SM and AT for group studies of healthy adults.