Vascular Inflammation: A Novel Access Route for Nanomedicine.
Vascular Inflammation: A Novel Access Route for Nanomedicine.
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DOI：
10.14797/mdcj-12-3-169
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发表时间：
2016-11
影响因子：
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通讯作者：
R. Molinaro;Christian Boada;Guillermo Medrano del Rosal;Kelly A. Hartman;C. Corbo;Elizabeth D Andrews;Naama E. Toledano-Furman;J. Cooke;E. Tasciotti
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文献类型：
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作者：
R. Molinaro;Christian Boada;Guillermo Medrano del Rosal;Kelly A. Hartman;C. Corbo;Elizabeth D Andrews;Naama E. Toledano-Furman;J. Cooke;E. Tasciotti
尽管人们对心血管疾病(CVD)的病理生理学有了更深入的了解，并有了一系列新的治疗方法，但它仍然是一个严重的公共卫生问题，也是美国死亡的头号原因。目前已知，促进慢性全身性炎症的疾病，如肥胖、癌症、自身免疫和感染性疾病，通过诱导内皮细胞黏附分子和趋化因子的表达，在促进CVD的过程中发挥重要作用；这些因素反过来又促进白细胞的黏附和渗透，从而启动和刺激CVD的进展。作为对这一新认识的回应，研究人员正在评估基于具有抗炎特性的内源性分子的新一代疗法的潜在心血管益处。同样，利用非炎症血管内皮细胞和炎症血管内皮细胞表型差异的靶向治疗方法有可能选择性地提供治疗药物，降低CVD患者的发病率和死亡率。在这篇综述中，我们讨论了炎症在CVD中的作用，并通过传统的和仿生的方法探索了靶向炎症血管的治疗潜力。
Despite an improved understanding of its pathophysiology and a wide range of new treatments, cardiovascular disease (CVD) remains a serious public health issue and the number one cause of mortality in the United States. Conditions that promote chronic systemic inflammation, such as obesity, cancer, and autoimmune and infectious diseases, are now known to play an important role in promoting CVD by inducing the expression of endothelial adhesion molecules and chemokines; these in turn promote leukocyte adherence and infiltration, which initiates and spurs the progression of CVD. In response to this new understanding, researchers are evaluating the potential cardiovascular benefits of new-generation therapies based on endogenous molecules with anti-inflammatory properties. Similarly, targeted approaches that leverage the phenotypic differences between non-inflamed and inflamed endothelia have the potential to selectively deliver therapeutics and decrease the morbidity and mortality of CVD patients. In this review, we discuss the role of inflammation in CVD and explore the therapeutic potential of targeting inflamed vasculature through conventional and biomimetic approaches.