Genetics of non-medullary thyroid cancer.
Genetics of non-medullary thyroid cancer.
复制标题
非髓样甲状腺癌的遗传学。
DOI：
10.1093/oxfordjournals.qjmed.a068992
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
M. Stratton
中科院分区：
文献类型：
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作者：
R. Houlston;M. Stratton
在联合王国，甲状腺癌的发病率在男性中为每10万人0.7例，在女性中为每10万人1.9例。1乳头状癌占所有病例的50%以上，其次是滤泡状癌。较少发生的类型是髓样癌、间变性癌、Hurthle细胞癌和鳞状细胞癌。大约25%的甲状腺髓样癌是家族性的，由RET癌基因缺陷引起。[2]相比之下，非髓样形式的甲状腺癌通常不被认为具有家族基础。然而，来自流行病学和家族研究的证据表明，这些癌症的一个子集也可能是由遗传易感性引起的。这些基因的鉴定可能有助于高风险人群的诊断和治疗，也可作为甲状腺癌发生的一般模型。
The incidence of cancer of the thyroid is 0.7 per 100 000 in males and 1.9 per 100 000 in females in the UK. 1 Papillary carcinoma accounts for more than 50% of all cases, followed by follicular carcinoma. Less frequent types are medullary, anaplastic, Hurthle cell and squamous cell carcinoma. About 25% of medullary thyroid carcinomas are familial, caused by defects in the RET oncogene. 2 By contrast, the non-medullary forms of thyroid cancer are not generally thought of as having a familial basis. However, evidence from epidemiological and family studies suggests that a subset of these cancers may also be caused by an inherited predisposition. Identification of the genes or genes may be useful for diagnosis and treatment of those at high risk, as well as serving as a model for thyroid carcinogenesis in general.