Effects of lithium dose (UCS) on the acquisition and extinction of a discriminated morphine aversion: tests with morphine and delta9-THC.
Effects of lithium dose (UCS) on the acquisition and extinction of a discriminated morphine aversion: tests with morphine and delta9-THC.
复制标题
锂剂量 (UCS) 对有区别的吗啡厌恶的获得和消除的影响：用吗啡和 delta9-THC 进行测试。
DOI：
10.1097/00008877-199907000-00002
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发表时间：
1999
影响因子：
1.6
通讯作者：
Lamb,RJ
中科院分区：
文献类型：
--
作者：
Jarbe,TU;Lamb,RJ
：在大鼠的辨别味觉厌恶 (DTA) 程序中，检查了不同锂剂量（无条件刺激 [UCS]；LiCl 范围 30-180 mg/kg）对 5.6 mg/kg 吗啡的刺激控制获得和消失的影响。此外，在获得和消失之间的测试阶段，通过用 (-)-δ-9-四氢大麻酚 (Δ9-THC) 替代吗啡来检查药理学特异性。 LiCl 剂量较高时，DTA 采集速度更快。 LiCl 的最低剂量 30 mg/kg 并不能有效维持 DTA。用 60 mg/kg LiCl 治疗的两组，仅使用的饮用喷嘴类型不同（滚珠轴承与标准非滚珠轴承），表现相似。大鼠的饮水抑制与吗啡剂量相关（剂量范围0.3-10mg/kg），在吗啡后加LiCl。对于在吗啡后注射生理盐水的大鼠，饮酒没有发生显着下降，可能除了 10 mg/kg 吗啡测试剂量外。饮酒的控制具有药理学特异性；在 DELTA 9-THC (0.3-10 mg/kg) 的测试中，实验动物和对照动物均受到同样的影响。低剂量的[DELTA] 9-THC 会增加耗水量；吗啡不会出现这种情况。在消退过程中，经过有效调节的各组的饮酒恢复情况相似，即锂剂量对消退没有明显影响。灭绝后，在 3 和 10 mg/kg 的试验中，吗啡发生的反应大大减弱。这些剂量的吗啡在灭绝阶段之前显着抑制了饮酒。总的来说，这些数据增加了感官和药物辨别刺激之间的形式相似性。
: The effects of varying the lithium dose (unconditioned stimulus [UCS]; LiCl range 30-180 mg/kg) on the acquisition and extinction of stimulus control by 5.6 mg/kg of morphine in a discriminated taste aversion (DTA) procedure were examined in rats. In addition, pharmacological specificity was examined by substituting (-)-delta-9-tetrahydrocannabinol ([DELTA] 9-THC) for morphine during a test phase intervening between acquisition and extinction. DTA acquisition was more rapid at higher LiCl doses. The lowest dose of LiCl, 30 mg/kg, did not robustly maintain a DTA. Two groups treated with 60 mg/kg LiCl, differing only in the type of drinking nozzle used (ball-bearing vs standard non-ball-bearing), behaved similarly. Suppression of drinking was related to the morphine dose, in an orderly manner (dose range 0.3-10 mg/kg), in rats for which morphine was followed by LiCl. No significant decline in drinking occurred for rats for which morphine was followed by saline, except perhaps at the 10 mg/kg test dose of morphine. The control of drinking was pharmacologically specific; both experimental and control animals were equally affected in tests with [DELTA] 9-THC (0.3-10 mg/kg). Low doses of [DELTA] 9-THC increased water consumption; this did not occur with morphine. During extinction the reinstitution of drinking was similar across groups that had been effectively conditioned, ie there was no apparent effect of lithium dose on extinction. After extinction, a much attenuated reaction occurred to morphine in tests with 3 and 10 mg/kg. These doses of morphine had significantly suppressed drinking before the extinction phase. Collectively, these data add to the formal similarities between sensory and drug discriminative stimuli.