Bilateral magnetic resonance imaging-determined hippocampal atrophy and verbal memory before and after temporal lobectomy
Bilateral magnetic resonance imaging-determined hippocampal atrophy and verbal memory before and after temporal lobectomy
复制标题
DOI：
10.1111/j.1528-1157.1996.tb00604.x
复制
发表时间：
1996-06-01
期刊：
影响因子：
5.6
通讯作者：
So, EL
中科院分区：
文献类型：
--
作者：
Trenerry, MR;Jack, CR;So, EL
我们调查了颞叶切除术患者的术前和术后的言语记忆，这些患者具有体积对称的脑半球。从15名左颞叶切除术患者和18名右颞叶切除术患者中获得基于韦氏记忆量表修订版（WMS-R）逻辑记忆子测试的术前和术后言语记忆数据。海马体积（R/L）之间的差异在-0.1和0.3 cm（3）之间，这对于侧海马萎缩是不确定的。根据手术侧和联合海马体积（表示为颅内总体积（R + L体积/颅内总体积）的函数）将患者分为4组。合并海马体积小于正常对照组任何合并海马值的患者被定义为双侧萎缩。左颞叶切除术患者的言语记忆力在术后均表现出预期的下降，无论是体积对称的大脑半球是非萎缩的还是萎缩的，然而，左颞叶切除术患者双侧大脑半球萎缩，手术前后的言语记忆力最差。右颞叶切除术后，无论容积对称的小脑半球是否萎缩，患者的言语记忆都有改善的趋势。我们的结论是，侧的操作是一个更有力的预测言语记忆的结果比海马萎缩时，双侧对称，左颞叶切除术患者双侧萎缩可能有风险更大的功能障碍手术后。
We investigated pre- and postoperative verbal memory in temporal lobectomy patients who had volumetrically symmetric hippocampi. Pre- and postoperative verbal memory data based on the Logical Memory subtest of the Wechsler Memory Scale-Revised (WMS-R) were obtained from 15 left and 18 right temporal lobectomy patients. The difference between hippocampal volumes (R/L) was between -0.1 and 0.3 cm(3), which is indeterminate for lateralizing hippocampal atrophy. Patients were divided into four groups based on side of operation and combined hippocampal volume expressed as a function of total intracranial volume (R + L volume/total intracranial volume). Patients with a combined hippocampal volume that was smaller than any combined hippocampal value of a normal control group were defined as bilaterally atrophic. Left temporal lobectomy patients demonstrated the expected decrease in verbal memory postoperatively regardless of whether the volumetrically symmetric hippocampi were nonatrophic or atrophic, Left temporal lobectomy patients with bilaterally atrophic hippocampi, however, had the poorest verbal memory before and after operation. Right temporal lobectomy patients tended to have improved verbal memory after operation whether or not the volumetrically symmetric hippocampi were atrophic. We conclude that side of operation is a more potent predictor of verbal memory outcome than is hippocampal atrophy when hippocampi are bilaterally symmetric and that left temporal lobectomy patients with bilateral atrophy may be at risk for greater functional deficits after operation.