Mesenchymal stem cells and their use as cell replacement therapy and disease modelling tool.
Mesenchymal stem cells and their use as cell replacement therapy and disease modelling tool.
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DOI：
10.1111/j.1582-4934.2008.00516.x
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发表时间：
2008-12
影响因子：
5.3
通讯作者：
Menendez P
中科院分区：
文献类型：
--
作者：
García-Castro J;Trigueros C;Madrenas J;Pérez-Simón JA;Rodriguez R;Menendez P
成体组织来源的间充质干细胞(MSCs)在体外和体内可分化为多种中胚层组织，包括骨、软骨、脂肪组织、肌腱、韧带甚至肌肉。骨髓间充质干细胞优先安置在受损组织中，在那里发挥其治疗潜力。MSCs的一个显著特征是其低固有免疫原性，因为它们几乎不能诱导同种异体淋巴细胞和抗原提呈细胞的增殖。相反，骨髓间充质干细胞在体外似乎具有免疫抑制作用。它们的多谱系分化潜力与其免疫特权特性相结合，正在全球范围内被用于自体和异体细胞替代策略。在这里，我们向读者介绍MSCs的生物学和免疫耐受的潜在机制。然后，我们根据MSCs的免疫学特性概述了潜在的细胞替代策略和临床应用。目前正在进行的临床试验包括移植物抗宿主病、骨髓间充质干细胞与造血干细胞联合移植后的造血恢复以及组织修复。最后，我们回顾了基于使用骨髓间充质干细胞作为自发或诱导肿瘤转化的靶细胞亚群，以及用于模拟非血液性间充质癌(如肉瘤)的新兴区域。
Mesenchymal stem cells (MSCs) from adult somatic tissues may differentiate in vitro and in vivo into multiple mesodermal tissues including bone, cartilage, adipose tissue, tendon, ligament or even muscle. MSCs preferentially home to damaged tissues where they exert their therapeutic potential. A striking feature of the MSCs is their low inherent immunogenicity as they induce little, if any, proliferation of allogeneic lymphocytes and antigen-presenting cells. Instead, MSCs appear to be immunosuppressive in vitro. Their multi-lineage differentiation potential coupled to their immuno-privileged properties is being exploited worldwide for both autologous and allo-geneic cell replacement strategies. Here, we introduce the readers to the biology of MSCs and the mechanisms underlying immune tolerance. We then outline potential cell replacement strategies and clinical applications based on the MSCs immunological properties. Ongoing clinical trials for graft-versus-host-disease, haematopoietic recovery after co-transplantation of MSCs along with haematopoietic stem cells and tissue repair are discussed. Finally, we review the emerging area based on the use of MSCs as a target cell subset for either spontaneous or induced neoplastic transformation and, for modelling non-haematological mesenchymal cancers such as sarcomas.
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影响因子：
11.4
作者：
Corre, J.;Mahtouk, K.;Bourin, P.
通讯作者：
Bourin, P.
影响因子：
82.9
作者：
Fändrich, F;Lin, XB;Binas, B
通讯作者：
Binas, B
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2.6
作者：
Devine, SM;Bartholomew, AM;Hoffman, R
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Hoffman, R
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11.2
作者：
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通讯作者：
Locatelli, Franco
影响因子：
20.3
作者：
Aggarwal, S;Pittenger, MF
通讯作者：
Pittenger, MF