Novel composite cement containing the anti-microbial compound CPC-Montmorillonite
Novel composite cement containing the anti-microbial compound CPC-Montmorillonite
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含有抗菌化合物CPC-蒙脱石的新型复合水泥
DOI：
10.1016/j.dental.2021.10.009
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发表时间：
2022
期刊：
影响因子：
5
通讯作者：
Yoshida Yasuhiro
中科院分区：
文献类型：
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作者：
Yamamoto Yuya;Yoshihara Kumiko;Nagaoka Noriyuki;Van Meerbeek Bart;Yoshida Yasuhiro
目的研究氯化十六烷基吡啶（CPC）改性蒙脱土复合骨水泥的力学性能、粘接性能和抗菌活性（'CPC-Mont'），并使用这些参数来确定复合水泥可以负载的CPC-Mont的最佳粒径和浓度。制备中值直径为30和7 μm的Mont颗粒，并以2、3、4、5和7.5重量%的浓度添加到复合水泥中。通过三点弯曲和微拉伸粘结强度测试，评价了复合水泥的力学性能和粘结性能。使用紫外-可见记录分光光度计定量从骨水泥盘释放的CPC的量。结果30 μ mCPC-Mont的加入降低了复合水泥的力学性能和粘结性能，而7 μ mCPC-Mont的加入没有降低复合水泥的力学性能和粘结性能。尽管CPC的释放在7天的评估期内显著降低，但5-和7.5-wt%的CPC-Mont负载的复合水泥抑制生物膜形成30 days. Significance用中值直径为7 μm的CPC-Mont以5-7.5 wt%的浓度负载复合水泥在实现连续的抗生物膜活性方面是有效的，同时保持机械强度和粘结性能。
ObjectivesThe aim of this study was to evaluate the mechanical properties, bonding performance and anti-microbial activity of a novel composite cement containing cetylpyridinium chloride (CPC) modified montmorillonite (‘CPC-Mont’), and using these parameters to determine the optimal particle size and concentration of CPC-Mont the composite cement can be loaded with.MethodsCPC-Mont particles with a median diameter of 30 and 7 µm were prepared and added to a composite cement at a concentration of 2, 3, 4, 5 and 7.5 wt%. Mechanical properties and bonding performance of the experimental composite cements were evaluated by 3-point bending and micro-tensile bond-strength testing. The amount of CPC released from the cement disks was quantified using a UV–vis recording spectrophotometer. The anti-biofilm activity was studied using scanning electron microscopy (SEM).ResultsAdding 30-μm CPC-Mont decreased the mechanical properties and bonding performance of the composite cement, while no reduction was observed for the 7-μm CPC-Mont loaded cement formulation. Although CPC release substantially decreased during the 7-day period assessed, 5- and 7.5-wt% CPC-Mont loaded composite cement inhibited biofilm formation for 30 days.SignificanceLoading composite cement with CPC-Mont with a median diameter of 7 µm at concentrations of 5–7.5 wt% was effective in achieving continuous anti-biofilm activity, while maintaining mechanical strength and bonding performance.