Rapid prototyping of cyclic olefin copolymer (COC) microfluidic devices
Rapid prototyping of cyclic olefin copolymer (COC) microfluidic devices
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DOI：
10.1016/j.snb.2017.03.023
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发表时间：
2017-08-01
影响因子：
8.4
通讯作者：
Fraden, Seth
中科院分区：
文献类型：
--
作者：
Aghvami, S. Ali;Opathalage, Achini;Fraden, Seth
本文介绍了一种低成本、高产量的COC微流控芯片的快速制造方法，适用于学术实验室和小型企业。器械由两个模制件组成，连接在一起形成密封器械。第一件包含微流体特征，第二件包含入口和出口歧管、用于刚性的框架和观察窗。使用PDMS模具图案化微流体特征，所述PDMS模具本身是从光致抗蚀剂母版复制模制的。COC装置的微流体部分的尺寸稳定性通过将PDMS模具限制在铝框架中来实现。该模具的盖子是数控铣削铝。COC装置的密封通过将盖定时浸入挥发性和非挥发性溶剂的混合物中，然后施加热和压力来完成。在组装的器械中使用多巴胺进行表面处理，使器械具有亲氟性。(C)2017爱思唯尔B.V.保留所有权利。
We introduce a low-cost, high yield rapid fabrication method for casting COC microfluidic chips that is appropriate for academic labs and small companies. Devices are comprised of two molded pieces joined together to create a sealed device. The first piece contains the microfluidic features and the second contains the inlet and outlet manifold, a frame for rigidity and a viewing window. The microfluidic features are patterned using a PDMS mold that itself was replica-molded from a photoresist master. Dimensional stability of the microfluidics portion of the COC device is achieved by confining the PDMS mold in an aluminium frame. The mold for the lid is CNC milled from aluminium. Sealing the COC device is accomplished by timed immersion of the lid in a mixture of volatile and non-volatile solvents followed by application of heat and pressure. Surface treatment to render the device fluorophilic is performed using dopamine in assembled devices. (C) 2017 Elsevier B.V. All rights reserved.