Effects of compensatory cognitive training intervention for breast cancer patients undergoing chemotherapy: a pilot study
Effects of compensatory cognitive training intervention for breast cancer patients undergoing chemotherapy: a pilot study
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DOI：
10.1007/s00520-017-3589-8
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发表时间：
2017-06-01
影响因子：
3.1
通讯作者：
Bae, Sun Hyoung
中科院分区：
文献类型：
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作者：
Park, Jin-Hee;Jung, Yong Sik;Bae, Sun Hyoung
许多乳腺癌患者在化疗过程中和化疗后都会经历认知变化。化疗相关的认知障碍会显著影响生活质量。这项初步研究试图确定代偿认知训练对接受辅助化疗的乳腺癌患者的客观和主观认知功能的影响。54名患者被分配到代偿认知训练或等待名单的条件下。分别在基线(T1)、干预12周结束时(T2)和干预结束后6个月(T3)进行评估。使用标准化的神经心理测试和癌症治疗-认知功能评估(FACT-Cog)第3版评估结果。原始数据根据基线分数转换为T分数，并使用重复测量的ANCOVA进行分析，调整了年龄、智力、抑郁和治疗。结果显示，随着时间的推移，干预组在客观认知功能方面比等待名单组有了显著的改善。在10项个体神经心理测量中，即时记忆、延迟记忆、类别流畅性和字母流畅性表现出显著的组间交互作用。在主观认知功能方面，与干预组相比，候补组患者的主观认知功能得分随着时间的推移而显著下降，12周的代偿性认知训练显著改善了乳腺癌患者的客观和主观认知功能。由于这是一项初步研究，有必要使用更大的样本和更长的跟踪时间进行进一步的研究。
Numerous breast cancer patients experience cognitive changes during and after chemotherapy. Chemotherapy-related cognitive impairment can significantly affect quality of life. This pilot study attempted to determine the effects of a compensatory cognitive training on the objective and subjective cognitive functioning of breast cancer patients receiving adjuvant chemotherapy.Fifty-four patients were assigned to either a compensatory cognitive training or waitlist condition. They were assessed at baseline (T1), the completion of the 12-week intervention (T2), and 6 months after intervention completion (T3). Outcomes were assessed using the standardized neuropsychological tests and the Functional Assessment of Cancer Therapy-Cognitive Function (FACT-Cog), version 3. Raw data were converted to T-scores based on baseline scores, and a repeated-measures ANCOVA, adjusting for age, intelligence, depression, and treatment, was used for analysis. The effect sizes for differences in means were calculated.The intervention group improved significantly over time compared to the waitlist group on objective cognitive function. Among ten individual neuropsychological measures, immediate memory, delayed memory, verbal fluency in category, and verbal fluency in letter showed significant group x time interaction. In subjective cognitive function, scores of the waitlist group significantly decrease over time on perceived cognitive impairments, in contrast to those of the intervention group.The 12-week compensatory cognitive training significantly improved the objective and subjective cognitive functioning of breast cancer patients. Because this was a pilot study, further research using a larger sample and longer follow-up durations is necessary.