Convergent synthesis and cytotoxic activities of 26-thio- and selenodioscin
Convergent synthesis and cytotoxic activities of 26-thio- and selenodioscin
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26-硫代和硒代辛的聚合合成和细胞毒活性
DOI：
10.1016/j.steroids.2013.05.018
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发表时间：
2013-09-01
期刊：
影响因子：
2.7
通讯作者：
Li, Ming
中科院分区：
文献类型：
--
作者：
Chen, Pengwei;Wang, Peng;Li, Ming
通过对chacotriosyl imidate进行高度立体选择性的1，2-transs糖基化反应，实现了26-硫代和硒代薯蓣皂苷的聚合嵌段合成。硫代薯蓣皂苷和硒代薯蓣皂苷都具有与薯蓣皂苷（一种天然螺甾烷醇糖苷）相似的细胞毒活性。(C)2013 Elsevier Inc. All rights reserved.
Convergent block syntheses of 26-thio- and selenodioscin have been achieved by developing the highly stereoselective 1,2-trans glycosylations of chacotriosyl imidate without recourse to neighboring group assistance. Both thiodioscin and selenodioscin possess cytotoxic activities similar to dioscin, a natural spirostanol glycoside. (C) 2013 Elsevier Inc. All rights reserved.