Membrane potentials and the mechanism of intestinal Na(+)-dependent sugar transport.
Membrane potentials and the mechanism of intestinal Na(+)-dependent sugar transport.
复制标题
膜电位和肠道Na()依赖性糖转运机制。
DOI：
10.1007/bf01869381
复制
发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Kimmich,GA
中科院分区：
文献类型：
--
作者：
Kimmich,GA
我们目前的理解Na+耦合传输系统的功能特性已经建立了使用各种各样的模型实验系统和几个不同的溶质传输系统。已经利用了不同的物种，并且针对除肠以外的组织中的Na+-偶联系统（特别是肾小管）的工作通常被认为是通过类比指向肠上皮的类似功能特性。模型的多样性和相关数据库的外推非常有用，是生物科学中大多数科学调查背后的重要力量。与此同时，探索方法的多样性和由此产生的所有肠道转运数据的统一解释的复杂性使得对性质的简明总结更加困难。一方面，在相关系统之间建立类比，以建立有用的范式供进一步考虑是很有吸引力的。另一方面，必须始终记住，当比较来自不同组织的数据时，甚至当比较不同物种之间肠组织的功能特性时，会有一些差异，并不总是细微的。此外，随着对Na+耦合运输系统功能的新认识，早期的工作可能会证明缺乏适当的控制，这使得很难在新的背景下提供简单或准确的解释。
Our current understanding of the functional characteristics of Na+-coupled transport systems has been established with the use of a wide variety of model experimental systems and for several different solute transport systems. Different species have been utilized and work aimed at Na+-coupled systems in tissues other than intestine, especially the renal tubule, has often been considered by analogy to point toward similar functional properties for the intestinal epithelium. This diversity of models and extrapolation of related data bases has been highly useful and is the vital force behind most scientific investigation in the biological sciences. At the same time, the diversity of exploration methodology and resultant complexity of a unified interpretation of all intestinal transport data renders a concise summary of properties more difficult. On the one hand, it is tempting to build analogy among related systems to establish useful paradigms for further consideration. On the other hand, it must always be remembered that there will be some differences, not always subtle, when comparing data derived from different tissues or even when comparing functional properties of intestinal tissue among different species. In addition, with new insights regarding function of Na+-coupled transport systems, earlier work may prove to lack appropriate controls, which makes it difficult to provide easy or accurate interpretation of that work in the new context.