Angiopoietin-2 gene polymorphisms are biomarkers for the development and progression of colorectal cancer in Han Chinese
Angiopoietin-2 gene polymorphisms are biomarkers for the development and progression of colorectal cancer in Han Chinese
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血管生成素2基因多态性是汉族结直肠癌发生和进展的生物标志物
DOI：
10.7150/ijms.37675
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发表时间：
2020-01-01
影响因子：
3.6
通讯作者：
Su, Chen-Ming
中科院分区：
文献类型：
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作者：
Du, Zhang;Tang, Chih-Hsin;Su, Chen-Ming
结直肠癌（CRC）是汉族人群中最常见的癌症之一，其特点是早期诊断率低，生存率低。血管生成素-2 （Ang2）是一种内皮酪氨酸激酶，参与CRC的进展，但对单核苷酸多态性（snp）与CRC的诊断或预后之间的关系知之甚少。本研究报道了Angpt2基因的5个snp位点（rs2442598、rs734701、rs1823375、11137037和rs12674822）与379例结直肠癌患者和1043例无癌健康对照者的结直肠癌易感性和临床结局之间的关系。携带rs1823375基因CG等位基因的携带者和携带rs12674822基因GT+TT等位基因的携带者患CRC的风险高于相应的野生型携带者。此外，与野生型（GG）携带者相比，rs12674822中GT或GT+TT等位基因携带者在结肠和直肠发生肿瘤的可能性明显更高，而携带rs12674822中GT+TT等位基因的患者的5年无进展生存率也明显低于野生型携带者。我们的研究首次描述了中国汉族人群中Angpt2多态性与结直肠癌发生进展之间的相关性。
Colorectal cancer (CRC) is one of the most common cancers in Han Chinese and is characterized by low rates of early diagnosis and poor survival rates. Angiopoietin-2 (Ang2), an endothelial tyrosine kinase, is involved in CRC progression, but little is known about the association between single nucleotide polymorphisms (SNPs) and diagnosis or prognosis of CRC. This study reports on the association between 5 SNPs of the Angpt2 gene (rs2442598, rs734701, rs1823375, 11137037, and rs12674822) and CRC susceptibility as well as clinical outcomes in 379 patients with CRC and in 1,043 cancer-free healthy controls. Carriers of the CG allele at rs1823375 and those with the GT+TT allele of the variant rs12674822 were at greater risk of CRC than their respective wild-type counterparts. Moreover, carriers of the GT or GT+TT allele in rs12674822 were significantly more likely to have tumor involvement in both the colon and rectum compared with wild-type (GG) carriers, while 5-year progression-free survival was also significantly worse in those carrying the GT+TT allele in rs12674822 compared with wild-type carriers. Our study is the first to describe correlations between Angpt2 polymorphisms and CRC development and progression in people of Chinese Han ethnicity.