The impact of warfarin on overall survival in cancer patients.
The impact of warfarin on overall survival in cancer patients.
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DOI：
10.1016/j.thromres.2021.11.004
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发表时间：
2022-05
影响因子：
7.5
通讯作者：
Zwicker, Jeffrey, I
中科院分区：
文献类型：
--
作者：
Chiasakul, Thita;Zwicker, Jeffrey, I
静脉血栓栓塞（VTE）是癌症患者常见的并发症。华法林已在很大程度上被低分子量肝素（LMWH）和直接口服抗凝剂（DOAC）取代，成为癌症相关VTE的标准治疗。在癌症人群中，这些抗凝剂相对于华法林的生存获益在临床试验中未得到证实，可能是由于样本量不足和随访时间有限。有新兴的基于人群的研究表明，华法林可能与改善癌症的总体生存率有关，并可能对某些类型的癌症具有保护作用。Warcantine可以通过凝血途径依赖性和非依赖性机制发挥其抗肿瘤特性，后者是通过抑制Gas 6-AXL信号传导途径介导的。进一步的研究应强调确定华法林有益作用的临床和实验室预测因素。本文就华法林对癌症患者的总体生存率和癌症发病率的潜在影响进行综述，并对其可能的作用机制和未来的发展前景进行展望。
Venous thromboembolism (VTE) is a common complication in patients with cancer. Warfarin has largely been replaced by low-molecular-weight heparin (LMWHs) and direct oral anticoagulants (DOACs) as the standard of care in cancer-associated VTE. The survival benefit of these anticoagulants over warfarin in the cancer population was not demonstrated in clinical trials, possibly due to insufficient sample size and limited follow-up duration. There are emerging population-based studies suggesting that warfarin may be associated with improved overall survival in cancers and may have a protective effect against certain types of cancers. Warfarin may exert its anti-neoplastic properties through both coagulation pathway -dependent and -independent mechanisms, the latter of which are mediated by inhibition of the Gas6-AXL signaling pathway. Further research should emphasize on identifying clinical and laboratory predictors of beneficial effects of warfarin. In this review article, we summarize and update the current evidence regarding the potential impact of warfarin on the overall survival of cancer patients and incidence of cancer, as well as review the potential mechanism of such effect and future perspectives.
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影响因子：
45.3
作者：
Key, Nigel S.;Khorana, Alok A.;Falanga, Anna
通讯作者：
Falanga, Anna
影响因子：
4
作者：
DALY, L
通讯作者：
DALY, L
影响因子：
8.8
作者：
FRANCIS, JL;CARTY, N;TAYLOR, I
通讯作者：
TAYLOR, I
DOI：
10.1038/nrc3004
发表时间：
2011-03
期刊：
Nature reviews. Cancer
影响因子：
--
作者：
Gay LJ;Felding-Habermann B
通讯作者：
Felding-Habermann B
影响因子：
6.7
作者：
Blumentals, WA;Foulis, PR;Mason, TJ
通讯作者：
Mason, TJ