The Big Book of Aldehyde Dehydrogenase Sequences
The Big Book of Aldehyde Dehydrogenase Sequences
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DOI：
10.1007/978-1-4615-4735-8_1
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发表时间：
1999
影响因子：
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通讯作者：
J. Perozich;H. Nicholas;R. Lindahl;J. Hempel
中科院分区：
文献类型：
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作者：
J. Perozich;H. Nicholas;R. Lindahl;J. Hempel
传统上，对乙醛脱氢酶(ALDHs，EC 1.2.1)的研究主要集中在三类：1类、2类和3类。1类和2类ALDH是关系非常密切的同源异构体，都参与乙醇代谢，尽管1类ALDH可以氧化广泛的代谢物，包括视网膜(回顾Lindahl，1982；Yoshida等，1)。第三类ALDH乍一看似乎与其他两类非常不同。3类ALDH与1类和2类ALDH只有大约25%的序列同源性，并且是同源二聚体。然而，在主链折叠中，2类和3类单体的结构几乎相同(Hempel等人，1999)。
Traditionally, research on aldehyde dehydrogenases (ALDHs, EC 1.2.1) has focused on three groups: class 1, 2, and 3 ALDHs. Class 1 and 2 ALDHsare very closely related homotetramers and both participate in ethanol metabolism, though class 1 ALDHscan oxidize wide range of metabolites, including retinal (reviewed Lindahl, 1982; Yoshida et al., 1). Class 3 ALDHsappear at first glance to be highly divergent from the other 2 classes. Class 3 ALDHsshare only about 25% sequence identity with class 1 and 2 ALDHs and are homodimers. However, in main-chain folding, the structures of the class 2 and 3 monomers are nearly identical (Hempel et al., 1999)